There are potential side effects including a very painful one—kidney stones—if levels are too high. Sometimes taking a supplement for one concern may raise another concern.
In one study, an antioxidant mixture containing vitamin C, vitamin E, melatonin and green tea extract was found to decrease fatigue in people with pancreatic cancer. As noted above, in one study people with melanoma treated with selenium had a lower later risk of developing lung, colon, or prostate cancer (but with an increased risk of diabetes.) Low blood levels of vitamin D are associated with an increased risk of several cancers, and a high vitamin D level is associated with a lower risk of developing breast and colorectal cancer. This theory is supported by a 2019 study published in The American Journal of Clinical Nutrition. Antioxidants may protect cancer cells from being damaged by chemotherapy and radiation therapy. The exception was one study which showed an increase in toxicity in those using a vitamin A supplement. The sun is a good source of vitamin D, requiring only short amounts of time with arms and face exposed to absorb upwards of 5000 IU's. Some research studies have also found connections between vitamin D levels in a person’s blood and their cancer risk.
In patients with advanced prostate cancer, PSA correlates with the amount of cancer in the body. The first reason is that it may be difficult to get an adequate amount of vitamin D by dietary measures. For this reason, many physicians recommend a supplement of vitamin D3.
Just as there are several reasons why people with cancer may wish to avoid vitamins, there are a number of reasons why they may be recommended instead.
People who have higher vitamin D levels at the time of diagnosis have longer survival rates from lung cancer than those with lower levels.
An example is a study in which people with melanoma were treated with selenium. A study recently published in the Journal of Clinical Oncology* found that the use of some vitamins and supplements before or during chemotherapy treatment for breast cancer was associated with increased recurrence and mortality rates.. Vitamins and supplements may interfere with or prevent the desired chemotherapy or radiation therapy effect of cell death, so it is …
Similar were findings with prostate cancer, in which dietary vitamin E is associated with a lower risk, but a study evaluating vitamin E supplements found an increased risk. The study showed that 81 percent of patients treated with the combination regimen cut their PSA levels by more than half. Vitamin and Mineral Supplements During Cancer Treatment Subramani, T., Yeap, S., Ho, W., Ho, C., Omar, A., Aziz, S., Rahman, N., and M. Alitheen. For example, in lab studies cancer cells appear to take up vitamin C better than normal cells. But as with other vitamins, it's important to talk to your doctor. Another theory that's been proposed is that receiving one antioxidant as a supplement may result in the body absorbing less or using less, of another important antioxidant. Examples of these include: A 2019 study also found antioxidant supplements may promote the spread (metastasis) of lung cancer. As a steroid hormone that regulates mineral homeostasis and bone metabolism, 1?, 25-dihydroxycholecalciferol (Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms.
Like vitamin D, vitamin B12 is not an antioxidant, and it's thought that many people over the age of 50 are deficient.
A 2008 study showed that vitamin C supplements decreased the effectiveness of chemotherapy by 30 to 70 percent among human leukemia and lymphoma cells in a laboratory setting.
Heaney, M., Gardner, J., Karasavvas, N., Golde, D., Scheinberg, D., Smith, E., and O. O’Connor. Googled: chemotherapy "vitamin d" - first entry is this VitaminDWiki page There have been many studies that have evaluated the role of vitamin D both in cancer prevention and in cancer treatment.
This article covers some of the possible risks and benefits of supplements, but it's important to note a few things.
Who should be taking a supplement? CONCLUSION: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.
In these studies it was thought that vitamin C interfered with apoptosis, that is, cell death, in cancer cells. A 2007 review of studies from 1966 to 2007 found no evidence that antioxidant supplements interfered with chemotherapy, and some researchers believe that antioxidants may help to protect normal cells without interfering with the effectiveness of cancer therapy.
Studies of docetaxel without calcitriol have reported a 42 percent PSA response rate overall.
In this study, postmenopausal women who too antioxidant supplements during chemotherapy and radiation therapy for breast cancer had poorer recurrence free survival and a higher mortality risk (were 64% more likely to die). Most oncologists recommend eating a healthy diet and do not believe the antioxidants derived from foods pose a threat to the effectiveness of cancer treatments. Researchers projected a two-thirds reduction in incidence with serum levels of 46ng/ml, which corresponds to a daily intake of 2,000 IU of vitamin D3.
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