Grapefruit has vitamin C and potassium—nutrients your body needs to work properly.But it isn’t good for you when it affects the way your medicines work, especially if you have high blood pressure or arrhythmia (irregular or abnormal heart beat).This food and drug interaction can be a concern, says Shiew Mei Huang, PhD, of the U.S. Food and Drug Administration.
Drug interactions are reported only by a few people who take Allopurinol and Magnesium chloride together. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.
Other drugs that have the same active ingredients (e.g.
Question 1. Grapefruit juice can affect how well some medicines work, and it may cause dangerous side effects. Allopurinol reduces the production of uric acid in your body. The result: too much drug in your body.The amount of the CYP3A4 enzyme in the intestine varies from person to person, says Huang. The study is created by eHealthMe based on reports of 3,019 people who take Allopurinol and Magnesium from the FDA, and is updated regularly. The FDA has required that some prescription and over-the-counter (OTC) drugs taken by mouth include warnings against drinking grapefruit juice or eating grapefruit while taking the drug, Huang says.Here are examples of some types of drugs that grapefruit juice can cause problems with (interact):Grapefruit juice does not affect all the drugs in the categories above. * Approximation only. Find patient medical information for Azathioprine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Intravenous admixtures – preparation and infusion guidelines. The study is created by eHealthMe based on reports of 3,019 people who take Allopurinol and Magnesium from the Food and Drug Administration (FDA), and is updated regularly. Some people have a lot of enzymes and others just a little. As a result, less of the drug enters the blood and the drug may not work as well, Huang says.When drugs are swallowed, they may be broken down (metabolized) by enzymes and/or absorbed using transporters in cells found in the small intestine. As shown above, grapefruit juice can block the action of these enzymes, increasing the amount of drug in the body and may cause more side effects.Other drugs, like Allegra (fexofenadine) used to treat allergies, are moved by transporters into the body’s cells.
Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. desmopressin (DDAVP, stimate) vaso pressin (Pitressin synthetic) (See the form of vaso in the drug name, for vaso constriction) ... Allopurinol (Zyloprim): client teaching. All rights reserved. Peds Dosing . Fexofenadine (brand name Allegra) is available as both prescription and OTC to relieve symptoms of seasonal allergies. down the sink or in the toilet) or in household garbage. This is a personalized study for a 58 year old male patient who has Diabetes Insipidus. Talk to your doctor, pharmacist or other health care provider and read any information provided with your prescription or OTC drug to find out:With most drugs that interact with grapefruit juice, “the juice lets more of the drug enter the blood,” Huang says. Uric acid buildup can lead to gout or kidney stones. Allopurinol oral tablet (Zyloprim) is an oral drug used to decrease uric acid levels. assess for increased urine production and give desmopressin (DDAVP) The client has hypothyroidism and is treated with levothyroxine (Synthroid). Allopurinol belongs to a group of drugs called enzymatic inhibitors; these substances act by controlling the speed to which occur a given chemical process in the body; in this case, allopurinol produces a lowering of uric acid level in plasma and urine. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects.
Although not all of these side effects may occur, if they do occur they may need medical attention. So grapefruit juice may affect people differently even when they take the same drug.Although scientists have known for several decades that grapefruit juice can cause too much of certain drugs in the body, Huang says more recent studies have found that the juice has the opposite effect on a few other drugs.“Grapefruit juice can cause less fexofenadine to enter the blood,” decreasing how well the drug works, Huang says. If you miss a dose, take it as soon as possible and continue with your regular schedule. “When there is too much drug in the blood, you may have more side effects.”For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure.Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine. It is a xanthine oxidase inhibitor which is administered orally.
Fexofenadine may also not work as well if taken with orange or apple juice, so the drug label states “do not take with fruit juices.”Why this opposite effect?
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