Researchers have cautioned against the use of antidepressant medications due to dangerous adverse effects. SSRIs and other antidepressants (mainly tricyclic antidepressants) were both associated with an elevated diabetes risk compared with no antidepressant use, with pooled multivariate-adjusted HRs of 1.10 (95% CI 1.00–1.22) and 1.26 (95% CI 1.11–1.42), respectively, but the risk did not appear to differ between antidepressant type.A retrospective cohort analysis using the Texas Medicaid prescription claims database studied 35,552 adults receiving antidepressants and 9,163 treated with benzodiazepines between 1 January 2002 and 31 December 2009 (The relationship among antidepressant use, glucose levels, and diabetes status was explored in 5,978 civil servants in the Whitehall II study during an 18-year period (In a Dutch pharmacy database study, 60,516 individuals were followed up from their first prescription for an antidepressant or benzodiazepine until end of registration or a first prescription for an antidiabetes drug (A recently published meta-analysis of 66 experimental studies dating back to 1960 included 42 studies of people without diabetes (Relevant studies were categorized according to medication type and effect. Case-control studies have reported an approximate doubling of diabetes rates in those taking antidepressants, with higher rates seen with higher doses, longer duration, or as combinations. Care to summarize the strategy?Anyway, I have pre diabetes which I indirectly blame on being on psych meds for years. Differing populations in age, baseline risk factors, and lifestyle, such as BMI and smoking status, prevent appropriate comparison. These differences provide challenges for the interpretation of the many observational studies that do not separate antidepressant types. K.B. The average absolute risk difference between women taking antidepressants and nonusers was 2.87 per 1,000 person-years. Researchers were able to control for a number of variables, such as body mass index (BMI), depressive symptoms, and whether the person was taking glucose-lowering medications.The researchers found that people without diabetes who were using SSRIs had lower insulin levels than those who were not taking antidepressants or those taking the older tricyclic antidepressants (TCAs). It will also be important to consider whether combination antidepressant treatment has additive effects. As an editor for blogs and personal stories at Mad in America, he prizes the accounts of those with lived experience of the psychiatric system and hopes to create alternatives to the biomedical model. We do not capture any email address.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Impaired Glucose RegulationAntidepressant Medication as a Risk Factor for Type 2 Diabetes and Impaired Glucose RegulationAntidepressants and body weight: a comprehensive review and meta-analysisHypoglycemia associated with maprotiline in a patient with type 1 diabetesGlucose dysregulation associated with antidepressant agents: an analysis of 17 published case reportsEffect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyperglycaemic miceThe The prevalence of co-morbid depression in adults with Type 1 diabetes: systematic literature reviewSystematic Reviews: CRD’s Guidance for Undertaking Reviews in Health CareSystematic Reviews in the Social Sciences: A Practical GuideMaking evidence synthesis more useful for management and policy-makingDepressive symptoms, antidepressant medication use, and insulin resistance: the PPP-Botnia StudyAssociation between depressive symptoms and metabolic syndrome is not explained by antidepressant medication: results from the PPP-Botnia StudyObesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland Health StudyIs ignorance bliss? This appears to be particularly relevant when it comes to patients with diabetes. A further study provided evidence of a dose-response, with a higher rate in those taking higher doses.There was evidence of reverse causality in one study that reported that among those who were not taking antidepressants at baseline, the proportion that began treatment with antidepressants was higher in those with a physician diagnosis of diabetes.
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