The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. After 3 days of dosing, the dose may be increased to the 300-mg-per-day target dose, given as … Because elderly patients are more likely to have decreased renal function, it may be necessary to consider this factor in dose selection; it may be useful to monitor renal function Consider a reduced dose and/or dosing frequency of bupropion hydrochloride extended-release tablets (SR) in patients with renal impairment (Glomerular Filtration Rate: less than 90 mL per min). Monitor cardiac rhythm and vital signs. When you try to quit smoking, with or without bupropion hydrochloride extended-release tablets, (SR), you may have symptoms that may be due to nicotine withdrawal, including: What other important information should I know about bupropion hydrochloride extended-release tablets, (SR)?eizures: There is a chance of having a seizure (convulsion, fit) with bupropion hydrochloride extended-release tablets, (SR)Do not take any other medicines while you are taking bupropion hydrochloride extended-release tablets, (SR) unless your healthcare provider has said it is okay to take them.If you have a seizure while taking bupropion hydrochloride extended-release tablets, (SR), stop taking the tablets and call your healthcare provider right away. For more information, ask your healthcare provider or pharmacist.Call your doctor for medical advice about side effects. The dose ranges from 174 mg to 522 mg.While there are dose ranges for each form, your health care provider will determine the form and dose that is right for you based on your response.The dose for SAD is bupropion XL 150 mg once daily in the morning. There are many dimensions to these choices, so be sure to confer with your doctor and caregivers.Bupropion has also been evaluated for smoking cessation during pregnancy and is recommended only after other therapies have failed.Regarding breast-feeding, caution is advised since bupropion does pass into breast milk.Bupropion hydrochloride is available in 3 different forms: immediate release (IR), sustained release (SR), and extended release (XL).Bupropion IR is usually taken 2 or 3 times per day with 4-6 hours between doses. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a relationship to drug exposure.Bupropion is primarily metabolized to hydroxybupropion by CYP2B6. Do not take more than your prescribed dose since higher doses may increase your risk of having a seizure. WELLBUTRIN SR prescription and dosage sizes information for physicians and healthcare professionals. Some people have had serious side effects while taking bupropion hydrochloride extended-release tablets, (SR), to help them quit smoking, including:Although bupropion hydrochloride extended-release tablets, (SR) are not a treatment for depression, it contains bupropion, the same active ingredient as the antidepressant medications WELLBUTRINThis section of the Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. The clinician should, nevertheless, be aware of the possibility of a drug interaction with such use Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 3 DOSAGE FORMS AND STRENGTHS Bupropion hydrochloride extended-release tablets USP (XL), 150 mg of bupropion hydrochloride, are white film coated tablet printed with "T101" on one side and plain on the other side. Doses for smoking cessation should not exceed 300 mg per day. Adverse reactions from Table 3 occurring in at least 5% of subjects treated with WELLBUTRIN SR and at a rate at least twice the placebo rate are listed below for the 300- and 400-mg-per-day dose groups. It is approved for the treatment of major depressive disorder (MDD), seasonal affective disorder (SAD), and to help people quit smoking (smoking cessation).Major depression occurs when a person experiences several of the following symptoms concurrently, for at least two weeks: "low" or depressed mood (for example, sad, empty, tearful), decreased interest in most or all activities, changes in appetite (usually decreased), changes in sleep (usually poor sleep), loss of energy, feeling worthless/guilty/hopeless/helpless, psychomotor agitation or retardation (i.e., thoughts/movements speeding up or slowing down), difficulty concentrating, and thoughts of death (suicidal thinking).SAD is a type of depression that occurs mainly during the autumn-winter season. The following information includes only the average doses of this medicine. The risk of hypertension is increased if bupropion hydrochloride extended-release tablets (SR) are used concomitantly with MAOIs or other drugs that increase dopaminergic or noradrenergic activity Data from a comparative trial of bupropion hydrochloride extended-release tablets (SR), nicotine transdermal system (NTS), the combination of bupropion hydrochloride extended-release tablets (SR) plus NTS, and placebo as an aid to smoking cessation suggest a higher incidence of treatment-emergent hypertension in patients treated with the combination of bupropion hydrochloride extended-release tablets (SR) and NTS.
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