It is also used to treat rhabdomyosarcoma (a type of cancer of the muscles) and Ewing's sarcoma (a type of bone cancer) in children. Advise females of reproductive potential to use effective contraception during treatment with Cyclophosphamide Injection and for up to 1 year after completion of therapy Based on findings in genetic toxicity and animal reproduction studies, advise male patients with female partners of reproductive potential to use effective contraception during treatment with Cyclophosphamide Injection and for 4 months after completion of therapy Amenorrhea, transient or permanent, associated with decreased estrogen and increased gonadotropin secretion develops in a proportion of women treated with cyclophosphamide.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Some degree of testicular atrophy may occur.
This interaction may result in an increased incidence of graft-versus-host disease.Depolarizing muscle relaxants: Cyclophosphamide treatment causes a marked and persistent inhibition of cholinesterase activity. If 400mg is greater than the actual cyclophosphamide dose then reduce the MESNA dose to 60% of the cyclophosphamide dose.¹⁸
Cefaclor extended-release tablets, cefpodoxime proxetil, and cefuroxime axetil oral suspension should be taken with food {30}1. Cytoxan (cyclophosphamide) Tablet Note: drug may be crushed but company recommends using injection Depakene (divalproex) Capsule Slow -release; mucus membrane irritant (b) Depakote (divalproex) Tablet Slow -release Depakote ER (divalproex) Tablet Slow -release Detrol LA (tolterodine) Capsule Slow -release At high doses, the fraction of parent compound cleared by 4-hydroxylation is reduced resulting in non-linear elimination of cyclophosphamide in patients. Cyclophosphamide belongs to a group of drugs called alkylating agents.
Some metabolites are protein bound to an extent greater than 60%. Your doctor will order certain lab tests to check your body's response to cyclophosphamide.It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Therefore, To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.Caution is advised when using this drug in children because they may be more sensitive to its effects, especially possible Some products that may interact with this drug include: If someone has overdosed and has serious symptoms such as passing out or For the best possible benefit, it is important to receive each scheduled dose of this Do not flush medications down the toilet or pour them into a drain unless instructed to do so. the Cyclophosphamide Infusion. Notify your doctor promptly if you develop any signs of an infection such as fever, chills or persistent This is not a complete list of possible side effects. Copyright(c) 2019 First Databank, Inc.Are you considering switching to Cyclophosphamide Vial?Are you planning to see a doctor about switching your medication?How long have you been taking Cyclophosphamide Vial?Are you planning to see a doctor about switching your medication?Selected from data included with permission and copyrighted by First Databank, Inc. Other intravenous regimens include 10 mg per kg to 15 mg per kg given every 7 to 10 days or 3 mg per kg to 5 mg per kg twice weekly.When cyclophosphamide is included in combined cytotoxic regimens, it may be necessary to reduce the dose of cyclophosphamide as well as that of the other drugs.Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.Cyclophosphamide does not contain any antimicrobial preservative and thus care must be taken to assure the sterility of prepared solutions.
Follow special handling and disposal proceduresCyclophosphamide Injection, 500 mg/2.5 mL Vial LabelCyclophosphamide Injection, 500 mg/2.5 mL Carton LabelThe easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. push, reconstitute with normal saline (NS) to a concentration of 20 mg/mL. The elimination half-life (tTotal body clearance (CL) of cyclophosphamide is decreased by 40% in patients with severe hepatic impairment and elimination half-life (tCyclophosphamide was mutagenic and clastogenic in multiple Cyclophosphamide is genotoxic in male and female germ cells.
The degree of neutropenia is particularly important because it correlates with a reduction in resistance to infections.
The results demonstrated that the systemic exposure to cyclophosphamide increased as the renal function decreased.
Infusion: Reconstituted Cyclophosphamide should be further diluted in 5% dextrose or 0.9% sodium chloride injection prior to infusion.
When cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body.
For any ambulatory patients the Mesna and dOnansetron should be prescribedon PICS and printed to Pharmacy Out -patients Dispensary so that patients can collect the medications to take at home. Cyclophosphamide has a molecular formula of C 7 H 15 Cl 2 N 2 O 2 P•H 2 O and a molecular weight of 279.1. Cyclophosphamide is a synthetic antineoplastic drug chemically related to the nitrogen mustards. Mesna.
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