DESCOVY for PrEP is indicated in at-risk adults and adolescents (≥35 kg) to reduce the risk of sexually acquired HIV-1 infection, excluding individuals at risk from receptive vaginal sex. In the DISCOVER trial, 5,387 study participants were randomized in a 1:1 ratio to receive either Descovy or Truvada once-daily. So it's important to find one that works for you. That is, it plans to switch up to 95% of patients under treatment with Truvada to Descovy by the fourth quarter of this year, O’Day said. If you have had kidney problems on Truvada, or have any medical condition that could impact your renal functioning, then Descovy might be a better choice. The consumer approach takes into consideration that we have the right to seek medical care from providers who offer us information, options, respect, and support. See below for Indication and Important Safety Information. It reflects an antiquated medical model in which a prescriber is in the parentified role of “expert” and the rest of us are passive “patients.” The problem with this top-down approach is that it rarely fosters engagement, empowerment, or consistent adherence to medications.I feel we’re better off using a “consumer” approach instead of a “patient” approach. After the primary analysis, there was one new HIV infection in the Descovy arm in a study participant with significantly reduced adherence for several months. This is why I strongly caution providers against using this hierarchical strategy in their communication with their consumers.Now let’s focus on Descovy and Truvada. In the DISCOVER study, which compared Descovy (which contains TAF) to Truvada (which contains TDF) for PrEP, triglyceride and LDL cholesterol levels increased at 48 weeks for people taking Descovy compared to no change or a decrease in people taking Truvada. Those who do are more likely to be older, have diabetes, and/or have chronic high blood pressure. Sexually transmitted infections (STIs) were assessed in three anatomic sites (oropharynx, urethra, rectum) at each study visit. Meeting Coverage > CROI Video Pearls Should PrEP Users Switch From Truvada to Descovy? Twice as many people started on statins in the Descovy group than in Truvada group (43 vs 21; 1.6% vs 0.8%). PrEP is an opportunity to change the narrative on historical mistrust of medical professionals and to build a lifelong rapport founded in choice, collaboration, respect, and consent. In order to make this choice, it’s important to be clear on what we know—and do not know—about these two drugs.About one in 200 people may have decreased kidney function because of taking Truvada for PrEP. TAF is a prodrug (or improved version) of TDF designed to be highly effective with a better safety profile than TDF. PrEP medications are most effective when you take them every day. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. Of the nine adverse events that occurred at a frequency of at least 10 percent in either study arm, six of the nine were sexually transmitted infections. Still, even if Gilead is overstating the benefits of Descovy, the data do show that Descovy is as effective as Truvada, with equally small—if different—risk of side effects. Gilead has committed to conducting a clinical trial that will evaluate the safety and efficacy of Descovy for PrEP in cisgender women and adolescent females weighing at least 35 kg and who are at risk of sexually acquired HIV-1 infection in HIV-1–negative status must be confirmed immediately prior to initiation. “The 96-week data from the DISCOVER trial further support the comparable efficacy of Descovy and Truvada for PrEP and offer new insights into the improved renal and bone safety profile of Descovy as measured by key bone and renal markers,” said In the DISCOVER trial, 1% of people on DESCOVY for PrEP stopped taking it because of side effects, compared to 2% of people taking TRUVADA* . Which suggests there is no actual harm in prescribing the newer drug. Results of these STI screenings demonstrate that participants maintained high-risk sexual risk behavior from study entry through the duration of the study. At Week 96, lumbar spine BMD increased by 0.95 percent in the Descovy group and decreased by 1.39 percent in the Truvada group (p<0.001). Week 96 data also demonstrated fewer cases of treatment-emergent proteinuria among patients taking Descovy than among those taking Truvada (p=0.003) and similar changes in urine protein:creatinine ratio across the two treatment groups (p=0.22). Truvada has pros and cons, just like Descovy. Descovy is also active against HBV. Yet less than three months later, my Facebook group Why are these providers in such a rush? But if you’re not having any kidney complications, and/or prefer the 2-1-1 dosing strategy, then you may want to wait until there are medical guidelines established that will help you make the healthiest and safest decision possible. Important U.S. Safety Information and Indication for Descovy for PrEP Truvada, which was approved for PrEP by the U.S. Food and Drug Administration (FDA) in 2012, contains emtricitabine and tenofovir disoproxil fumarate (TDF).
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