Desloratadine is well absorbed with maximum concentration achieved after approximately 3 hours; the terminal phase half-life is approximately 27 hours. By continuing to browse the site you are agreeing to our policy on the use of cookies. Nevertheless, as there is individual variation in response to all medicinal products, it is recommended that patients are advised not to engage in activities requiring mental alertness, such as driving a car or using machines, until they have established their own response to the medicinal product.In clinical trials in a range of indications including allergic rhinitis and chronic idiopathic urticaria, at the recommended dose of 5 mg daily, undesirable effects with desloratadine were reported in 3% of patients in excess of those treated with placebo.
The degree of accumulation of desloratadine was consistent with its half-life (approximately 27 hours) and a once daily dosing frequency. In the multiple-dose study, steady state was reached after Day 11, and compared to healthy subjects the exposure to desloratadine was ~1.5-fold greater in subjects with mild to moderate CRI and ~2.5-fold greater in subjects with severe CRI. This site uses cookies. DESLORATADINE SANDOZ 5 MG KALVOPÄÄLLYSTEINEN TABLETTI 30 FOL Reseptilääkkeet 2 ,56 € DESLORATADIN MYLAN 5 MG KALVOPÄÄLLYSTEINEN TABLETTI 30 FOL Reseptilääkkeet Desloratadine is moderately bound (83 % - 87 %) to plasma proteins. Available for Android and iOS devices.We comply with the HONcode standard for trustworthy health information - Symptomatic and supportive treatment is recommended.Desloratadine is not eliminated by haemodialysis; it is not known if it is eliminated by peritoneal dialysis.Based on a multiple dose clinical trial, in which up to 45 mg of desloratadine was administered (nine times the clinical dose), no clinically relevant effects were observed.The adverse event profile associated with overdosage, as seen during post-marketing use, is similar to that seen with therapeutic doses, but the magnitude of the effects can be higher.Desloratadine is a non-sedating, long-acting histamine antagonist with selective peripheral HDesloratadine has demonstrated anti-allergic properties from In a multiple dose clinical trial, in which up to 20 mg of desloratadine was administered daily for 14 days, no statistically or clinically relevant cardiovascular effect was observed. Therefore, caution is recommended if alcohol is taken concomitantly.A large amount of data on pregnant women (more than 1,000 pregnancy outcomes) indicate no malformative nor foeto / neonatal toxicity of desloratadine. In persistent allergic rhinitis (presence of symptoms for 4 days or more per week and for more than 4 weeks), continued treatment may be proposed to the patients during the allergen exposure periods.There is limited clinical trial efficacy experience with the use of desloratadine in adolescents 12 through 17 years of age (see sections 4.8 and 5.1).The safety and efficacy of Desloratadine 5 mg film-coated tablets in children below the age of 12 years have not been established. It allows continued monitoring of the benefit/risk balance of the medicinal product. Desloratadine effectively controlled symptoms for 24 hours. The originating document has been archived. No significant differences were found in the psychomotor test results between desloratadine and placebo groups, whether administered alone or with alcohol.In patients with allergic rhinitis, desloratadine was effective in relieving symptoms such as sneezing, nasal discharge and itching, as well as ocular itching, tearing and redness, and itching of palate.
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