Objective: To study the efficacy of divalproex in the treatment of PTSD.
Research Design: This is an 8-week randomized, double-blind, placebo-controlled treatment trial of divalproex.
METHOD: Under double-blind conditions, 85 US military veterans with PTSD were randomized to treatment with divalproex or placebo for 8 weeks. Objective: To study the efficacy of divalproex in the treatment of PTSD.
Intrusion and hyperarousal symptoms decreased significantly, while no significant change was seen in avoidance/numbing symptoms.
An investigator is available by telephone 24 hrs a day in case of emergency. You have reached the maximum number of saved studies (100).Please remove one or more studies before adding more.Keywords provided by VA Office of Research and Development:Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): doi: 10.1186/1471-244X-14-S1-S1. Depakote (Divalproex) is an anticonvulsant used to prevent seizures.
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It is sometimes used in conjunction with other seizure medications. Epub 2016 Jan 7.Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M; Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University, Antony MM, Bouchard S, Brunet A, Flament M, Grigoriadis S, Mendlowitz S, O'Connor K, Rabheru K, Richter PM, Robichaud M, Walker JR.BMC Psychiatry.
Clark RD(1), Cañive JM, Calais LA, Qualls CR, Tuason VB. OBJECTIVE: To evaluate the efficacy of divalproex for the treatment of posttraumatic stress disorder (PTSD) hyperarousal symptom cluster. 2014;14 Suppl 1(Suppl 1):S1. Epub 2014 Jul 2.Curr Ther Res Clin Exp. Research Design: This is an 8-week randomized, double-blind, placebo-controlled treatment trial of divalproex.Methodology: After signing an informed consent and meeting all inclusion/exclusion criteria, the patient is randomized to either divalproex or placebo for an 8-week duration. 2008 Feb;28(1):84-8. doi: 10.1097/JCP.0b013e318160f83b.Ducrocq F, Vaiva G, Cottencin O, Molenda S, Bailly D.Psychopharmacology (Berl). 2009 May 29;9:28. doi: 10.1186/1471-244X-9-28.Brain Res.
Posttraumatic stress disorder (PTSD) is characterized by intrusive, avoidance, and hyperarousal symptoms. Plasma valproate levels were measured at the 8-week post-treatment assessment. Author information: (1)Department of Pharmacy, VA Medical Center, Albuquerque, New Mexico 87108, USA. Patients are given supportive clinical management during the clinic visits. Sixteen patients with a DSM-IV diagnosis of PTSD at the Albuquerque VAMC outpatient PTSD treatment program received an open-label trial of divalproex.
HAM-A scores also decreased significantly. This study was conducted to investigate the effectiveness of divalproex in reducing PTSD symptoms, depression, and anxiety in patients with PTSD. Wiley Depressive symptoms, as measured by the HAM-D, unexpectedly decreased at post-treatment assessment. Please enable it to take advantage of the complete set of features! Patients may be seen more often if needed.
During the study a pharmacist maintains the randomization log and administers the placebo or divalproex (500 mg/capsule) in look-a-like tablets.
The dosing is twice daily, with the higher dose at bedtime. COVID-19 is an emerging, rapidly evolving situation.
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