The mean increase in QTc from baseline for ziprasidone was 4.6 msec following the first injection and 12.8 msec following the second injection. In order to ensure use of the lowest effective dose, patients should ordinarily be observed for improvement for several weeks before upward dosage adjustment.Efficacy in schizophrenia was demonstrated in a dose range of 20 mg to 100 mg twice daily in short-term, placebo-controlled clinical trials. These symptoms have varied in severity. Hypokalemia may result from diuretic therapy, diarrhea, and other causes. Less than one-third of ziprasidone metabolic clearance is mediated by cytochrome P450 catalyzed oxidation.Ziprasidone should not be used with any drug that prolongs the QT interval Given the primary CNS effects of ziprasidone, caution should be used when it is taken in combination with other centrally acting drugs.Because of its potential for inducing hypotension, ziprasidone may enhance the effects of certain antihypertensive agents.Ziprasidone may antagonize the effects of levodopa and dopamine agonists.Carbamazepine is an inducer of CYP3A4; administration of 200 mg twice daily for 21 days resulted in a decrease of approximately 35% in the AUC of ziprasidone. Single-dose vials require reconstitution prior to administration.Add 1.2 mL of Sterile Water for Injection to the vial and shake vigorously until all the drug is dissolved. The conditions and duration of treatment with ziprasidone included open-label and double-blind studies, inpatient and outpatient studies, and short-term and longer-term exposure.Clinical trials for intramuscular ziprasidone included 570 patients and/or normal subjects who received one or more injections of ziprasidone. Ziprasidone should be discontinued in patients who are found to have persistent QTc measurements >500 msec.For patients taking ziprasidone who experience symptoms that could indicate the occurrence of torsade de pointes, e.g., dizziness, palpitations, or syncope, the prescriber should initiate further evaluation, e.g., Holter monitoring may be useful.A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with administration of antipsychotic drugs. In arriving at a diagnosis, it is important to exclude cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) There have been few reports of hyperglycemia or diabetes in patients treated with Geodon. In the double-blind randomized phase, patients continued treatment with lithium or valproic acid and were randomized to receive either ziprasidone (administered twice daily totaling 80 mg to 160 mg per day) or placebo. Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Appropriate care is advised when prescribing ziprasidone for patients who will be experiencing conditions which may contribute to an elevation in core body temperature, e.g., exercising strenuously, exposure to extreme heat, receiving concomitant medication with anticholinergic activity, or being subject to dehydration.The possibility of a suicide attempt is inherent in psychotic illness or bipolar disorder, and close supervision of high-risk patients should accompany drug therapy. Antihistamine nasal sprays help relieve sneezing, itchy or runny nose, sinus congestion, and postnasal drip.
Intranasal corticosteroids are the most effective treatment and should be first-line thera… Precise risk estimates for hyperglycemia-related adverse reactions in patients treated with atypical antipsychotics are not available.Patients with an established diagnosis of diabetes mellitus who are started on atypical antipsychotics should be monitored regularly for worsening of glucose control. All interactions studies have been conducted with oral ziprasidone. Available for Android and iOS devices. Treatment should be based on the patient's age and severity of symptoms. Long-standing hyperprolactinemia when associated with hypogonadism may lead to decreased bone density.Somnolence was a commonly reported adverse reaction in patients treated with ziprasidone. In case of acute overdosage, establish and maintain an airway and ensure adequate oxygenation and ventilation. The safety of doses above 100 mg twice daily has not been systematically evaluated in clinical trials While there is no body of evidence available to answer the question of how long a patient treated with ziprasidone should remain on it, a maintenance study in patients who had been symptomatically stable and then randomized to continue ziprasidone or switch to placebo demonstrated a delay in time to relapse for patients receiving Geodon Dose Selection-Oral ziprasidone should be administered at an initial daily dose of 40 mg twice daily with food.
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