Side effects may include:More information on side effects can be found in the patient information leaflet for leflunomide, which will come with your medicine.Remember to report any concerns about possible side effects to the doctors, pharmacists or nurses.The recommendation is that alcohol consumption should be avoided during treatment with leflunomide as there is the possibility of increased toxic effects on the liver.There is no research evidence on the effects and safety of vaccinations for anyone taking leflunomide, therefore vaccination is not recommended.This article has been taken from our 'Medicines in Rheumatoid Arthritis booklet.
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See our And some contain a substance called lecithin, which can be harmful to people allergic to peanuts or soya.If you have psoriasis and find your skin becomes inflamed or infected once you’ve started taking leflunomide, speak to your doctor.If your doctor thinks your reaction is serious they may suggest you have a washout treatment to remove the leflunomide from your body quickly.A washout treatment consists of taking either activated powdered charcoal or a drug called cholestyramine (co-la-sti-ra-meen) for 11 days. Leflunomide (Arava) works about as well as methotrexate and can work even better in combination with it.
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Some people find it gives them loose bowel movements or diarrhoea (dy-a-ree-ah) but this usually settles down after a couple of weeks.Some people do experience hair loss, but this is quite rare and usually minor.Leflunomide reduces the amount of blood cells your body makes, which means you could pick up infections more easily.Tell your doctor or rheumatology nurse straight away if you develop any signs of infection, such as:You should also see your doctor if you come into contact with anyone who has chickenpox or shingles, or if you develop chickenpox or shingles yourself.These viruses can affect you badly when you’re taking leflunomide. 0000036978 00000 n
Leflunomide is used to treat the symptoms of rheumatoid arthritis. The inhibition of human DHODH by A77 1726, the active metabolite of leflunomide, occurs at levels (approximately 600 nM) that are achieved during treatment of RA. Leflunomide was previously started with a three-day ‘loading dose’ of 100mg daily, but this has generally been stopped as it led to significant problems with diarrhoea.Leflunomide acts on an enzyme in the body to limit the excessive reaction of the cells involved during inflammation, thereby reducing the swelling, pain and problems of RA.Leflunomide persists for a long time in the body so that any change of treatment to a different drug must be carefully managed to avoid the potential that the side effects from both leflunomide and the next drug might cause problems. How does Cabergoline work? Leflunomide is a potent immunosuppressant, reducing resistance to infection which, when it occurs, can be severe and disseminated. If you have missed a dose of leflunomide, don’t take any more than your regular dose to make up for it.If you take too much, you may experience side effects.
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