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Q: Can some vitamin and mineral supplements be taken once a week instead of daily? Because vitamin D3 is fat soluble (meaning that it's stored in your fat), it's also better absorbed by your body when you take it with fat .
Although the initial dose of 45,000 IU vitamin D3 produced an initial transient increase in serum 1,25(OH)S.I.-S. has received grant support from Aventis (2004), Eli-Lilly (1996, 2000, 2004, 2005-present), Beaufour Ipsen Group (2001), Merck Sharp & Dome (1997, 2000, 2002), Novartis (2003), NPS (2003), Medison Pharma (2001), Sunlight Ultrasound Technologies (1999), Neopharm Pharmaceutical (1998), Smith Kline Beecham (1997), and Transpharma (2007-present).Disclosure Summary: B.R.,T.S., and I.L.B. An RCT evaluated 38 postmenopausal women (median age 61.5 years) randomized into 3 groups (placebo or daily oral vitamin DIn another RCT that evaluated 48 women (average age 81±8 years) with hip fracture, the same cumulative dose of vitamin DAfter 4 months, the 600 IU daily dose increased mean serum 25(OH)D levels the most, by 18.9 ng/mL; the 4200 IU weekly dose increased levels by 16.3 ng/mL, and the 18,000 IU monthly dose increased levels the least, by 11 ng/mL (All subjects had serum 25(OH)D levels below 32 ng/mL at baseline. The use of 1500 IU/d was intended to serve as a loading dose. Take it once a day, take it twice a day. 11th ed. We were concerned that large intermittent, monthly doses of vitamin D might cause transient hypercalcemia because of a mass-action effect on the production of 1,25-dihydroxyvitamin D [1,25(OH)The study population comprised 48 women, aged 81 ± 8 yr (± Blood was collected at baseline d 0, before the first dose, and at 24 h after the dose, 1 wk and 4 wk after the first dose; the same sampling sequence was repeated during the second month of therapy. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwideFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
Mean serum PTH concentrations were significantly lower by the end of the study protocol in the weekly and the monthly dose groups (Effect of dosing frequency and of 8-wk vitamin D supplementation on serum 25(OH)D, PTH, and albumin-corrected calcium concentration for each treatment protocolStatistically significantly different from concentration at baseline, based on significant analysis of variance, followed by Effect of dosing frequency and of 8-wk vitamin D supplementation on serum 25(OH)D, PTH, and albumin-corrected calcium concentration for each treatment protocolStatistically significantly different from concentration at baseline, based on significant analysis of variance, followed by To characterize the effect of initial 25(OH)D concentration on the concentration attained at d 56, we pooled all subjects in the study and stratified them according to the initial concentration of 25(OH)D (Pooled results for all 48 patients, stratified according to the serum 25(OH)D concentration on d 0 (Pooled results for all 48 patients, stratified according to the serum 25(OH)D concentration on d 0 (For decades, various dose intervals for vitamin D supplementation or treatment have been in use, including annual injections, a pill every fourth month, as well as monthly, weekly, and daily doses (Aside from the expected initial differences in serum 25(OH)D and 1,25(OH)The results obtained with vitamin D in ethanol are applicable to other formulations of vitamin D. We recently demonstrated that bioavailability, based on serum 25(OH)D response, of high-dose vitamin D that was fortified into cheddar cheese, or into low-fat cheddar, when consumed weekly, is identical in a direct comparison with bioavailability using vitamin D in ethanolic solution, as in the present protocol (One potential limitation of the present study is that it was not blinded. For the last five years or so, I am taking 5,000 IU/day of vit D-3 for 5 days per week, and my vitamin level is around 60 ng/ml. If the initial serum 25(OH)D is less than 20 ng/ml, then patients probably need to be started on a daily equivalent dose of vitamin D3 that is more than 1500 IU because half of them will not have attained that goal. Once-weekly administration has been studied mostly in developing countries, because deficiencies are … One month after a single 300,000 IU dose, serum 25(OH)D levels increased by 47.8±7.3 ng/mL in the oral DThe Institute of Medicine (IOM’s) 2011 report on dietary requirements for calcium and vitamin D doesn’t address the ideal treatment of deficiency, but it states that adequate levels of serum 25(OH)D are 20 ng/mL—not 30 ng/mL.
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