Bone loss is greater with increasing duration of use and may not be completely reversible. However, medroxyprogesterone acetate injectable suspension has not been causally associated with the induction of thrombotic or thromboembolic disorders. What should I tell my healthcare provider before taking medroxyprogesterone acetate injectable suspension?
Table 4 shows the change in BMD in women after 5 years of treatment with medroxyprogesterone acetate injectable suspension and in women in a control group, as well as the extent of recovery of BMD for the subset of the women for whom 2-year post treatment data were available. WHO (1991): age, center, and age at first live birth. Altered menstrual bleeding patterns include amenorrhea, irregular or unpredictable bleeding or spotting, prolonged spotting or bleeding, and heavy bleeding. You should also learn about other birth control methods to choose the one that is best for you. The more carefully you follow the directions (such as returning every 3 months for your next injection), the less chance you have of getting pregnant. Some drugs or herbal products that may decrease the effectiveness of hormonal contraceptives include: Consult the labeling of all concurrently used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations. In five clinical studies using medroxyprogesterone acetate injectable suspension, the 12-month failure rate for the group of women treated with medroxyprogesterone acetate injectable suspension was zero (no pregnancies reported) to 0.7 by Life-Table method. Il s'utilise pour prévenir une grossesse.
Mean decreases in BMD of the total hip and femoral neck were similar. When switching from other contraceptive methods, medroxyprogesterone acetate injectable suspension should be given in a manner that ensures continuous contraceptive coverage based upon the mechanism of action of both methods, (e.g., patients switching from oral contraceptives should have their first injection of medroxyprogesterone acetate injectable suspension on the day after the last active tablet or at the latest, on the day following the final inactive tablet). Medroxyprogesterone injectable suspension can interact with other medications, herbs, or vitamins you might be taking. The following important adverse reactions observed with the use of medroxyprogesterone acetate injectable suspension are discussed in greater detail in the Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Its metabolism primarily involves ring A and/or side-chain reduction, loss of the acetyl group, hydroxylation in the 2-, 6-, and 21- positions or a combination of these positions, resulting in more than 10 metabolites. Medroxyprogesterone acetate injectable suspension, USP, 150 mg/mL, 1 mL vial “See FDA-approved patient labeling (Patient Information).”What is the most important information I should know about medroxyprogesterone acetate injectable suspension? Si plus de 14 semaines s'écoulent entre les injections SC, on doit effectuer un test de grossesse pour éliminer la possibilité d'une grossesse avant de reprendre un traitement avec la médroxyprogestérone. These are not all the possible side effects of medroxyprogesterone acetate injectable suspension. Neonates and infants exposed to medroxyprogesterone from breast milk have been studied for developmental and behavioral effects through puberty. (It is unknown if use of medroxyprogesterone acetate injectable suspension during adolescence or early adulthood, a critical period of bone accretion, will reduce peak bone mass and increase the risk for osteoporotic fracture in later life. Medroxyprogesterone acetate injectable suspension can pose an additional risk in patients with risk factors for osteoporosis (e.g., metabolic bone disease, chronic alcohol and/or tobacco use, anorexia nervosa, strong family history of osteoporosis or chronic use of drugs that can reduce bone mass such as anticonvulsants or corticosteroids). [Detectable amounts of drug have been identified in the milk of mothers receiving medroxyprogesterone acetate injectable suspension.
After stopping use of medroxyprogesterone acetate injectable suspension (150 mg), there was partial recovery of BMD toward baseline values during the 2-year post-therapy period. Talk to your healthcare provider about the best way to feed your baby if you take medroxyprogesterone acetate injectable suspension. Updated Copy the URL below and paste it into your RSS Reader application. The following chart shows the chance of getting pregnant for women who use different methods of birth control.
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