Iams JD, Goldenberg RL, Mercer BM, et al. encoded search term (What is the role of nifedipine in the treatment of preterm labor?) Diseases & Conditions Effect of maternal work activity on preterm birth and low birth weight. The length of the cervix and the risk of spontaneous premature delivery. Continuous monitoring of the fetal heart rate is recommended as long as the patient has contractions; the patient's pulse and blood pressure should be carefully monitored. “Was hospitalized for 3 days at 32 weeks after showing signs of preterm labor. Reprinted from Society for Maternal-Fetal Medicine Publications Committee, with assistance of Vincenzo Berghella. This site needs JavaScript to work properly. Initial dose: 20 mg of nifedipine (2 capsules of 10 mg). Porto AM, Coutinho IC, Correia JB, Amorim MM. A healthy, normal pregnancy lasts 40 weeks. Gibbs RS, Romero R, Hillier SL, Eschenbach DA, Sweet RL. Two dose regimens of nifedipine for management of preterm labor: a randomized controlled trial. Re-evaluating the role of the MFM specialist: lead, follow, or get out of the way. Rouse DJ. If contractions persist, therapy can be continued with 20 … The preterm prediction study: a clinical risk assessment system. Patterns of weight gain in adolescent pregnancy: effects on birth weight and preterm delivery. After 72 hours, if maintenance is still required, long-acting nifedipine 30-60 mg daily can be used.Contraindications of nifedipine therapy include allergy to nifedipine, hypotension, hepatic dysfunction, concurrent use of beta-mimetics or MgSO4, transdermal nitrates, or other antihypertensive medication.
Women with singleton pregnancies admitted in preterm labor (24 to 34 weeks) were randomized to high-dose (HD) nifedipine ( N = 49; 20 mg loading dose, repeated in 30 minutes, daily 120 to 160 mg slow-release nifedipine for 48 hours followed by 80 to 120 mg daily until 36 weeks) or low-dose (LD) nifedipine ( N = 53; 10 mg, up to four doses every 15 minutes, daily 60 to 80 mg slow-release nifedipine for 48 hours followed by 60 mg daily until 36 weeks). Nifedipine is a calcium antagonist that has the advantages of being orally administered and cheap. Mid-trimester endovaginal sonography in women at high risk for spontaneous preterm birth. Clipboard, Search History, and several other advanced features are temporarily unavailable. Macones GA, Robinson CA. Despite its unlabeled status, several randomized studies have shown that the use of nifedipine in comparison with other tocolytics is associated with a more frequent successful prolongation of pregnancy, resulting in significantly fewer admissions of newborns to the neonatal intensive care unit, and may be associated with a lower incidence of RDS, necrotizing enterocolitis, and intraventricular hemorrhage.A systemic review by Conde-Aqudelo found that nifedipine was associated with significantly fewer maternal adverse events than βA recommended initial dosage of nifedipine is 20 mg orally, followed by 20 mg orally after 30 minutes. 1-4 Preterm labor … The review concluded that nifedipine appeared to be a more effective tocolytic agent than beta2-adrenergic-receptor agonists and better tolerated compared with beta2-adrenergic-receptor agonists and magnesium sulfate in women with preterm labour.
Epub 2010 Jul 16.Int J Womens Health. We compared two dose regimens of tocolytic oral nifedipine. Magnesium for neuroprophylaxis: fact or fiction?. Higby K, Xenakis EM, Pauerstein CJ. We compared two dose regimens of tocolytic oral nifedipine. ACOG practice bulletin. COVID-19 is an emerging, rapidly evolving situation. Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes. The diagnosis and natural history of false preterm labor. Papiernik E, Bouyer J, Dreyfus J, et al. Elder MG, Hendricks CH, eds. American College of Obstetricians and Gynecologists. Preterm labor is defined as the presence of uterine contractions of sufficient frequency and intensity to effect progressive effacement and dilation of the cervix prior to term gestation (between 20 and 37 weeks).
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