font-size: inherit!important; Proin is a medication developed to manage urinary incontinence in dogs. line-height: inherit!important;
border-radius: 2px; Every effort has been made to ensure the accuracy of the Proin Chewable Tablets (25 mg) information published above.
It was pulled from use, however, after the side effects with were deemed too dangerous.Through various studies,it was shown that the side effect only appeared in humans. Four of 6 dogs in the 10X group had heart rates below the normal range on day 7, whereas none of the control dogs did. In addition, one dog exhibited disorientation, nervousness, a 7.7% loss of body weight, and hypertension with proteinuria.
One or more systolic blood pressure readings of > 160 mmHg2. Side Effects of Proin. There were more dogs with ALT levels above the normal range in the 3 PPA-treated groups compared to the control, but increased values were transient and less than 1.8X ULN. The most common adverse reactions are listed in Table 2 below. I have a senior male dog - around 12 years old, although we can't be sure since he Proin - Senior Male Dog and Urinary Incontinence - Dogs - - Page 2 - City-Data Forum City-Data Forum > General Forums > Pets > Dogs Give as directed by your veterinarian. Keep PROIN ER in a secured location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.Contact your veterinarian immediately if the dog ingests more tablets than prescribed or if other pets ingest PROIN ER. Pract. The 10X dogs had hypertensive mean MAP values on days 7 and 21, whereas the control dog mean MAP values were in the normal range. Proin is a veterinarian-prescribed medication for dogs that contains the active ingredient phenylpropanolamine 3. } In humans, phenylpropanolamine is readily absorbed after oral administration of solid dosage forms and has an onset of action of approximately 15-30 minutes and duration of effect of about three hours. PROIN Chewable Tablets are scored and contain the active ingredient phenylpropanolamine hydrochloride (PPA), USP, in three different strengths: 25 mg, 50 mg and 75 mg per tablet in a palatable formulation.PROIN Chewable Tablets are indicated for the control of urinary incontinence due to urethral sphincter hypotonus in female dogs.PROIN Chewable Tablets may cause hypertension; therefore, the use of this drug is contraindicated in dogs with high blood pressure due to chronic hypertension.Since the safe use of PROIN Chewable Tablets has not been evaluated in dogs intended for reproductive purposes, during pregnancy or in lactating bitches, this drug should not be administered to breeding, pregnant or lactating dogs.PROIN Chewable Tablets should be used with caution in dogs with pre-existing heart disease, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension.PROIN Chewable Tablets may interact with the use of other drugs. A necropsy of one dog revealed subarachnoidal and intraventricular hemorrhage in the brain.For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions, call Pegasus Laboratories at 1-800-874-9764.Contact your veterinarian if you notice restlessness or irritability, loss of appetite, persistence or worsening of the incontinence, or any other unusual signs.Consult your veterinarian before using PROIN Chewable Tablets with any other medications.The pharmacokinetics of phenylpropanolamine in dogs has not been well studied.
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The dogs averaged just over one accident per dog per week. body .resources_btn:hover, body.et-db #et-boc .et-l .resources_btn:hover {
Not for human use. .resources_btn { opacity: 1;
There was a trend in 10X dogs for lower heart rates following initiation of PPA treatment. /* ----------------------------------------- */ Of these, one dog developed systolic failure with an unknown relation to treatment.1.
Dogs were randomly assigned either to receive 2 mg/kg PROIN Chewable Tablets (123 dogs) or placebo (61 dogs… This drug should be stored out of reach of dogs in a secured area.1. Proin for dogs is a drug that is prescribed for urinary incontinence. color: #009681!important; display:inline-block;} .et_pb_button_wrapper .resources_btn, .et_pb_button_wrapper .resources_btn:hover {
padding-top: 10px!important; One dog had emesis and died at home; upon necropsy a foreign body was present in the small intestine.
Incontinence is the inability to consciously control the bladder resulting in involuntary leakage of urine.Sometimes urinary incontinence is minor without only small quantities of urine escaping and causing a ‘dribble’ of urine here and there. Although less common, male dogs may also experience urinary incontinence. Noel, S., et al. background-color: #009681!important; The 3X and 5X groups had higher mean serum ALT values compared to the control.
padding-right: 2em; Proin is a prescription medication for veterinary use in dogs. line-height: inherit; It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using these data. Proin is available as 25mg, 50mg and 75mg chewable, liver flavor tablets. .resources_btn:after {
Keep the product in a secured storage area out of the reach of pets in order to prevent accidental ingestion or overdose, as dogs may willingly consume more than the recommended dosage of PROIN Chewable tablets. padding-left: 0.7em;
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