Compare Telmisartan vs Valsartan head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Unauthorized The actigraphy data were used to determine the onset and offset times of diurnal activity and nocturnal sleep so as to accurately determine the diurnal and nocturnal BP means of each subject. Micardis (telmisartan) lowers your risk of heart attack and stroke.
For example, the morning BP rate of rise coincident with the commencement of diurnal activity has been verified to be an independent risk factor of stroke in older Japanese patients with hypertension.A number of previous publications revised elsewhereResults of this randomized prospective trial indicate that 80 mg/d of telmisartan efficiently reduces BP for the entire 24 hours whether the once-daily ingestion is consistently in the morning on awakening from nighttime sleep or at bedtime at night (International guidelines for the treatment of hypertension recommend the use of long-acting, once-daily medications that exhibit 24-hour efficacy; they improve adherence to therapy and minimize BP variability with smoother and more consistent BP control.The potential reduction in cardiovascular risk associated with the normalization of the circadian variability of BP (converting a nondipper to dipper pattern) has not yet been clearly established.
Blood pressure was measured for 48 hours before and after 12 weeks of treatment. 2149 0 obj <>stream We studied 215 patients with hypertension (114 men and 101 women), 46.4±12.0 years of age, randomly assigned to receive telmisartan (80 mg/d) as a monotherapy either on awakening or at bedtime. Sandoz Telmisartan HCT (80 mg telmisartan/25 mg hydrochlorothiazide) is indicated for: treatment of patients whose blood pressure is not adequately controlled by Sandoz Telmisartan HCT 80/12.5 mg or patients who have been previously stabilised on telmisartan and hydrochlorothiazide given separately.
The demographic characteristics of the 2 groups of participants (at baseline and after the 12 weeks of treatment) are described in Blood samples were obtained in the clinic from the antecubital vein after nocturnal fasting between 8:00 The SBP, DBP, and heart rate (HR) of each participant were automatically measured every 20 minutes from 7 Every participant wore a Mini-Motion-Logger Actigraph (Ambulatory Monitoring Inc) on the dominant wrist to monitor physical activity every minute of the day and night throughout each 48-hour ABPM session. Nocturnal BP regulation is significantly better achieved with bedtime dosing of telmisartan. Geriatrics (> 65 years of age): No dosing adjustment is necessary. Shift workers, heavy drinkers (alcohol intake >80 g/d), heavy smokers (>20 cigarettes per day), and heavy exercisers were excluded, as were individuals with either severe arterial hypertension (grade 3, eg, BP ≥180/110 mm Hg), type 1 diabetes, or secondary arterial hypertension and cardiovascular disorders, including concomitant unstable angina pectoris, heart failure, stroke, life-threatening arrhythmia, nephropathy, and retinopathy or previous (within the last year) myocardial infarction or coronary revascularization as revealed by thorough clinical evaluation according to the standardized protocol at the hypertension unit of the hospital. h��[]����+��_U�M���m`zP�Y[�� ���V�����4���R�]�L��6���S��,��8���t�9����O#e��S��h�����R��R�S�r�R�TF;��=U�i�VN��Ө�-�NCk95q�)���k�6鹟�z��?�����]*�5�i�=��R]�J����E�J�.� J/�*Y]��"�LRŢsth)�Vj�M\Y+~W�>"��R����9O���Z݄���C\�nM�j�W���6[{ Zydus did not provide a reason for the shortage. Micardis tablet, Boehringer Ingelheim, 20 mg, bottle, 30 count, NDC 00597-0039-37; During the inclusion period, we screened 262 diurnally active patients and identified 231 who met the inclusion/exclusion criteria. Telmisartan belongs to a class of medications known as angiotensin II receptor antagonists. It is used to treat mild to moderate high blood pressure.When blood pressure is allowed to remain high for a long time, the blood vessels of the heart, kidneys, and brain may become damaged. Q5�0�c=Z�N1��j k�ZÚ��-���B��-ͧ�)v����I�{5�haXݚew��9Ę�c�յ�h9D�˦�{��l���gk�1]�aMWkX���,ztkCg�[s��V 1��cTC�C��b����,1����1G}��Q$�6J�1�}���Һ���>Űf�>��Hab��ѧ�q�)�4�c64��q�$.��4s�BS 1̫1;\��bhפ.� 7�S����ZK%�����*]k:�$a��ÚM�HX9KX�'G�)K�S�m*sk"��|�]�)Pg��a?E�&%M�'^�<0c��g�� G�v�6'*��� �r��������5�����I.Z8]KXe�am̙t5٧gvsk>�u!� tk~��Z)��g���0��t�;�4����b@A�[s��C��\��{��I�!�2g�y��>5�5wq��u�n��)ia��ְ�WkX�5��j k6]�Mp��6&���sM�\�bĸ�o���&������\�jdz�s���� p��Z�|(.�9��������֣kX[��am=��5]�a�VkX����j kc��1��s�������V������Z^�%����ZY�n��z�[k�t�a��7����&5�k�'Ú����Vd��6��t��Y�%��`�X�\"R��e��͗���%=G�Zp�3�$o qrp���iRz���K|� �.�d}X�u�a��ְ��5�Eg���fm�am�ְ6V�[s~�b 1Pb�%N(�խ9I�eEC��Np��m Telecomunicación, Campus Universitario, Vigo (Pontevedra) 36200, Spain. %PDF-1.5 %���� Among these, 215 (114 men and 101 women), 46.4±12.0 years of age, completed the study and provided all of the required information for this trial.After providing informed consent to participate in this prospective, randomized, open-label, blinded end point, parallel-group chronotherapy trial, patients were randomly assigned to 1 of 2 groups according to the time of day, either in the morning on awakening from nighttime sleep or at bedtime at night, of ingestion of the single daily tablet of telmisartan (80 mg/d, the highest recommended dose in Spain) for 12 weeks. Telmisartan rated 5.8/10 vs Valsartan rated 5.7/10 in overall patient satisfaction.
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