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Please confirm that you would like to log out of Medscape. Swallow whole. Maintenance dose: 200 mg orally once or twice a day. Cardiac effects and drug interactions.Not for treatment of onychomycosis in patients with ventricular dysfunction (eg, CHF).
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Sporanox (itraconazole) is an antifungal medication that fights infections caused by fungus.Sporanox is used to treat infections in adults caused by fungus, which can invade any part of the body including the lungs, mouth or throat, toenails, or fingernails.
Close more info about SPORANOX Close more info about SPORANOX 1077685-overview Sporanox. 2002 CHF risk (eg, ischemic/valvular disease, COPD, renal failure, edema); monitor and discontinue if occurs. Advise females of reproductive potential to use highly effective contraception during and for 2 months after therapy. This website also contains material copyrighted by 3rd parties. Concomitant colchicine, fesoterodine, or solifenacin in renal/hepatic impairment.
Immunocompromised: adjust dose based on clinical response. Results of …
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200 mg PO qDay; If no improvement, or evidence of progressive fungal disease, increase dose in 100-mg increments to a maximum of 400 mg/day; Divide doses >200 mg/day into 2 doses… Pregnancy. Histoplasmosis.
The recommended dose is 200 mg once daily (2 capsules). Diseases & Conditions If there is no obvious improvement, or there is evidence of progressive fungal disease, the dose should be increased in 100-mg increments to a maximum of 400 mg daily. Drugs mcg/mL (fed)Trough plasma concentration: 1.2 mcg/mL (Tolsura 130 mg BID); 1 mcg/mL (itraconazole 200 mg BID)Peak plasma concentration (steady-state): 1.6 mcg/mL (Tolsura 130 mg BID); 1.5 mcg/mL (itraconazole 200 mg BID)Peak plasma concentration (Onmel): 162 ng/mL (fasted); 213 ng/mL (fed)Peak plasma time (steady-state): 7 hr (Tolsura 130 mg BID); 5 hr (itraconazole 200 mg BID)Peak plasma time (Onmel): 2.9 hr (fasted); 5.7 hr (fed)Extensively metabolized by the liver into a large number of metabolitesMain metabolite is hydroxy-itraconazole, which has in vitro antifungal activity comparable to itraconazole; trough plasma concentrations of this metabolite are about twice those of itraconazoleAdding plans allows you to compare formulary status to other drugs in the same class.To view formulary information first create a list of plans. Discontinue if neuropathy or hearing loss occurs. Renal impairment. Elderly. Duration of therapy: At least 3 months and until clinical parameters and laboratory tests indicate the active fungal infection has subsided.
Drugs Serious cardiac effects with cisapride, pimozide, methadone, quinidine, others. Cystic fibrosis: switch to alternative therapy if no response.
Your list will be saved and can be edited at any time.The above information is provided for general Life-threatening conditions: may give loading dose of 200mg three times daily for 1Treatment of onychomycosis in CHF, pregnancy, or contemplating pregnancy. Capsules) in which patients with onychomycosis of the toenails received 200 mg of SPORANOX. Blastomycosis. Monitor for signs/symptoms of liver dysfunction; discontinue and perform LFTs if develop. Congestive heart failure. and formulary information changes. Diseases & Conditions Doses above 200 mg/day should be given in two divided doses.
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