A second 25 mg of captopril was given if the target of 25% reduction of BP was not reached after the first tablet. Oral Captopril in Hypertensive CrisisCopyright © 2016 Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Background and objectives: Hypertensive crisis is a condition characterized by rapid and inappropriate symptomatic elevation of blood pressure (BP) that is commonly seen in Emergency Departments. An additional 25 mg of sublingual captopril was administered to the remaining 47 patients (46.5 percent).
This site needs JavaScript to work properly. In 14, a second administration was necessary after 30 minutes, and a satisfactory response to the second dose, defined again as DBP reaching values of 100 mm Hg or less, was achieved in 12 of them (29% of the total group).
Name must be less than 100 characters Sublingual captopril (25 mg) was administered and the blood pressure was measured during a follow-up period of 120 minutes.
2008 Jan 23;2008(1):CD003653. Singapore Medical Association We selected the patients to the groups consecutively. Clipboard, Search History, and several other advanced features are temporarily unavailable. An initial electrocardiogram was obtained and blood samples were drawn. It exhibits peak effect 1 - 2 hours after oral administration . Unable to load your collection due to an error Sublingual nifedipine has been shown to be highly effective. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username 2003 Dec;28(8):717-24. doi: 10.1007/s00059-003-2506-8.Nagy V, Zámolyi K, Szegedi N, Szegedi N, Székács B.Musuc AM, Anuta V, Atkinson I, Popa VT, Sarbu I, Mircioiu C, Abdalrb GA, Mitu MA, Ozon EA.Pharmaceutics.
Unable to load your collection due to an error The unpleasant taste of the sublingual drugs causes uncomfortable condition to the patient. Please enable it to take advantage of the complete set of features! However, the blood pressure fall following nifedipine is frequently associated with side-effects. Herein we compared the oral and sublingual captopril efficiency in the hypertensive urgencies. We conclude that sublingual captopril is effective in patients with hypertensive emergencies and that captopril may be an excellent alternative to sublingual nifedipine in the urgent treatment of hypertensive crisis. Captopril is an ACEI that has been administered orally and sublingually in hypertension urgencies (7, 9-23).
Dadkar VN(1), Karnik ND, Izar M, Sharma SR, Gandhi YP, Narawane NM, Vyawahare SS, Sudhakar S, Gore AG, Kapadia NM, et al. Sublingual captopril (25 mg) was compared with sublingual nifedipine (10 mg) to determine their effectiveness and safety in the treatment of hypertensive emergencies. The use of sublingual captopril has recently been indicated in hypertensive crisis, assuming that by this route, there would be a faster absorption and thus a more rapid effect on blood pressure than with the oral route.
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To verify this hypothesis, we have compared the hypotensive effects of sublingual nifedipine and sublingual captopril in 52 patients with hypertensive emergencies: 25-mg captopril and 10-mg nifedipine were administered sublingually to 28 and 24 patients, respectively.
Forty‐one patients, presenting in the Emergency Service of the Hospital General y Clinico, Tenerife, with symptoms of hypertensive crisis and supine diastolic blood pressure (DBF) > 120 mm Hg, were studied. Intravenous drugs were administered to the patients resistant to the captopril and these patients were excluded from the study.The 10-min systolic BP (SBP), diastolic BP, and mean BP (MBP) decrease was more prominent in the sublingual captopril group (In our study, sublingual captopril was found to decrease BP more efficiently in the first 30 min, but this difference equalized at 60 min.We use cookies to help provide and enhance our service and tailor content and ads. Sublingual Captopril in comparison to oral Captopril causes an earlier increase in plasma Captopril concentration and … Results: After 60 minutes, an ideal decrease (25 percent of the initial blood pressure) was detected in 54 patients (53.5 percent).
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