Theophylline has a narrow therapeutic window, with a therapeutic plasma level of 10–15 mg/L and toxicity beginning at 15–20 mg/L. Current License Must Be On File Prior To Shipping. Drugs such as enrofloxacin, cimetidine, clindamycin, lincomycin, allopurinol and erythromycin can increase the potentially harmful side effects of theophylline.
Select one or more newsletters to continue. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username The dose should be repeated at intervals of 6 to 12 hours as required. Multi ingredient medications may also be listed when applicable. Beagles administered 100 mg aminophylline IV had a T½, Cl, and Vd of 4.5 hr, 2.1 mL/min/kg, and 0.834 L/kg (Shiu, et al, 1989). Theophylline is a bronchodilator, which means it's a substance that works to open up airways. Carver Biotechnology Center, University of Illinois, Urbana, IllinoisThe Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IllinoisThe Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IllinoisJennifer M. Reinhart, The Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802.The Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IllinoisThe Metabolomics Center, Roy J. Overall, the MCT product investigated showed similar pharmacokinetic characteristics compared to previously validated extended‐release theophylline products. All Rights Reserved. Theophylline is a commonly used bronchodilator drug for treatment of chronic canine bronchitis, but no formulations validated in dogs are currently available.
Do not use two doses at one time.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Theophylline reduces the effectiveness of beta blockers. Give your pup theophylline only as directed by your vet to prevent an overdose. Mild toxicity manifests in roughly 30% of patients at concentrations of 15 mg/L. Submit license if not already on file. In contrast a study in mixed-breed dogs administered aminophylline 12 mg/kg, equivalent to 9.4 mg/kg, theophylline IV, resulting in a mean theophylline T½ and Vz of 5.7 hr and 0.8244 L/kg (McKiernan, et al, 1981). Give the medicine on an empty stomach, which is an hour before or 2 hours after food intake. The suggested dosage of theophylline for dogs is 4.5 to 6.8mg per pound by mouth every 12 hours and for cats 2mg/lbs in every 8-12 hours. High blood pressure 6.
The molecular formula of anhydrous theophylline is C 7 H 8 N 4 O 2 with a molecular weight of 180.17.. Theo-24 is available as capsules intended for oral administration, containing 100 mg, 200 mg, 300 mg, or 400 mg of anhydrous theophylline per capsule, in an extended-release formulation which allows a 24-hour dosing interval for appropriate patients. An oral, modified and compounded theophylline product (MCT), which could fulfil this need, is available through a USP‐compliant, veterinary compounding pharmacy; however, its pharmacokinetic properties are unknown. Theophylline (brand names: Theo-24®, Theochron®, Elixophyllin®, Theodur®) is a bronchodilator used to treat coughs caused by bronchospasm or bronchoconstriction.
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