"Novo Nordisk Pharmaceuticals, Inc., the manufacturer of repaglinide, also supported this trial Dr. Raskin received grant support from Novo Nordisk for this clinical trial, and he is a member of its medical scientific advisory board. All material on this website is protected by copyright, Copyright © 1994-2020 by WebMD LLC. 2020 Mar 18;6:5. doi: 10.1186/s40780-020-00159-7. 2005–.Terawaki Y, Iwaya C, Nomiyama T, Shimono D, Horikawa T, Fujimura-Tanaka Y, Shigeoka T, Hamanoue N, Motonaga R, Tanabe M, Yanase T, Kawanami D; Collaborators in the Repaglinide Glucose Oscillation Study in Fukuoka (REGO-F) trial.Diabetol Int. doi: 10.1055/s-0029-1212168.2009 Apr 6. The frequency of hypoglycemic events is 0.016 events per patient per month for subjects treated with repaglinide, as compared with 0 events per patient per month (Mean weight gains (adjusted for baseline and age) from baseline to end of study were +1.8 kg for repaglinide and +0.7 kg for nateglinide (IMI method calculation, The most common adverse events (between 3 and 10% of patients in both treatment groups) were upper respiratory tract infection, sinusitis, constipation, arthralgia, headache, and vomiting. Rifampicin. There was no significant difference between repaglinide and nateglinide groups in the effects of reducing fasting blood glucose (FBG), 30-, 60- and 120-min BG during 12 weeks (p > 0.05). You must declare any conflicts of interest related to your comments and responses.
"This study provides information to healthcare providers directly comparing these two agents. At week 12, no significant difference was shown between the two groups in BG or haemoglobin A 1c (HbA 1c) (p > 0.05). This website also contains material copyrighted by 3rd parties. The two treatment groups were significantly different in blood glucose values at all time points (Characteristics of randomized population at baseline and completion statusChanges in glycemic control during 16 weeks of treatmentThis study was supported by Novo Nordisk Pharmaceuticals of Princeton, New Jersey.J.R. Mean changes in FPG also demonstrated significantly greater efficacy for repaglinide than nateglinide (-57 vs. -18 mg/dl; P < 0.001). However, that clinical … 1999;107 Suppl 4:S133-5. Free PMC article During the three months preceding enrollment, HbA "This clinical trial was the first direct comparison of repaglinide monotherapy and nateglinide monotherapy," lead author Mohammed F. Saad, MD, FRCP, a professor of medicine at the University of California at Los Angeles, told Medscape. Please see our Please enter a Recipient Address and/or check the Send me a copy checkbox. Name must be less than 100 characters You must declare any conflicts of interest related to your comments and responses. Baseline (mean) 8.2: 8.0: 8.2: Change from baseline (mean) 0.01-0.4-0.6: Difference from metformin -0.4*-0.6† Add-On Combination Therapy With Rosiglitazone. and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username
Aims/Introduction: Repaglinide is a short-acting insulin secretagogue.
The primary efficacy end points for comparison were final HbAEnrolled patients had been treated with only diet and exercise during the previous 3 months (HbAA liquid test meal evaluation (two cans of Boost equal 480 kcal; 67% carbohydrate, 17% protein, and 16% fat) was conducted at the baseline and week 16 visits with determination of plasma glucose (hexokinase assay), insulin (immunometric assay), and glucagon (radioimmunoassay) from −10 min to 240 min (Icon Laboratories). Semaglutide. Median final doses were 5 mg/day for repaglinide and 360 mg/day for nateglinide. and D.R.H. Free PMC article Starlix (nateglinide) can quickly lower your blood sugar, but needs to be timed with your meals. "This study demonstrated that these two mealtime oral treatments for type 2 diabetes differ in their efficacy, with patients having approximately 0.5% lower HbA Patients were randomized to treatment with repaglinide (0.5 mg/meal; maximum of 4 mg/meal) or nateglinide (60 mg/meal increased to 120 mg/meal if needed) to reach preprandial glycemic targets of 90 to 140 mg/dL. For allocation of the participants, a computer‐generated list of random numbers was used. Unable to load your collection due to an error
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