In all studies, there was no significant difference between the drug and placebo group in the rate or type of reported adverse reactions nor were there any differences in abnormal clinical laboratory findings.Overdosage by topical application of acyclovir ointment 5% is unlikely because of limited transcutaneous absorption (see Apply sufficient quantity to adequately cover all lesions every 3 hours, 6 times per day for 7 days.
These studies were designed to evaluate the dermal tolerance, systemic toxicity, and percutaneous absorption of acyclovir.In 1 of these studies, which included 16 inpatients, the complete ointment or its vehicle were randomly administered in a dose of 1-cm strips (25 mg acyclovir) 4 times a day for 7 days to an intact skin surface area of 4.5 square inches. Virest 5% Cream is used for the treatment of herpes simplex viral infections of the skin including initial and recurrent genital herpes and herpes labialis. Required fields are marked * Although topical acyclovir will not cure herpes simplex, it may help relieve the pain and discomfort and may help the sores (if any) heal faster. Acyclovir, USP, is a synthetic nucleoside analogue active against herpes viruses. Changed from Zovirax Cream 5% w/w to (i.e. In studies in immunocompromised patients mainly with herpes labialis, there was a decrease in duration of viral shedding and a slight decrease in duration of pain.In studies of recurrent genital herpes and of herpes labialis in nonimmunocompromised patients, there was no evidence of clinical benefit; there was some decrease in duration of viral shedding.Acyclovir ointment 5% is indicated in the management of initial genital herpes and in limited non-life-threatening mucocutaneous Herpes simplex virus infections in immunocompromised patients.Acyclovir ointment 5% is contraindicated in patients who develop hypersensitivity to the components of the formulation.Acyclovir ointment 5% is intended for cutaneous use only and should not be used in the eye.In the controlled clinical trials, mild pain (including transient burning and stinging) was reported by about 30% of patients in both the active and placebo arms; treatment was discontinued in 2 of these patients. Each gram of acyclovir ointment, USP 5% contains 50 mg of acyclovir, USP in a polyethylene glycol (PEG) base. Therefore, systemic absorption of acyclovir after topical application is minimal.In clinical trials of initial genital herpes infections, acyclovir ointment 5% has shown a decrease in healing time and, in some cases, a decrease in duration of viral shedding and duration of pain. Two clinical pharmacology studies were performed with acyclovir ointment 5% in immunocompromised adults at risk of developing mucocutaneous Herpes simplex virus infections or with localized varicella-zoster infections. Each gram of acyclovir ointment, USP 5% contains Carcinogenesis, Mutagenesis, Impairment of Fertility:Therapy should be initiated as early as possible following onset of signs and symptoms.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Topical acyclovir may also be used for other conditions as determined by your doctor.Acyclovir is available only with your doctor's prescription.This product is available in the following dosage forms:Portions of this document last updated: March 01, 2020Copyright © 2020 IBM Watson Health. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes.
Usually they work for only one kind or group of virus infections.Topical acyclovir is used to treat the symptoms of herpes simplex virus infections of the skin, mucous membranes, and genitals (sex organs). Acyclovir is available only with your doctor's prescription.
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