More than 5,000 male and more than 4,000 female patients received vildagliptin 50 mg once daily or 100 mg daily. This medicine is not recommended for use in patients with type 1 diabetes and diabetic ketoacidosis.The amount of time required for this medicine to show its action is not clinically established.The amount of time for which this medicine remains active in the body is not clinically established.Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.This medicine is not recommended for use in pregnant women unless absolutely necessary.
In these cases, the patients were generally asymptomatic without clinical sequelae and liver function test results returned to normal after discontinuation of treatment. After 1 year, mean reductions in HbAIn a 24-week trial the efficacy of the fixed dose combination of vildagliptin and metformin (gradually titrated to a dose of 50 mg/500 mg twice daily or 50 mg/1000 mg twice daily) as initial therapy in drug-naïve patients was evaluated. Sign In. Get Best Price. Studies in animals have shown reproductive toxicity at high doses (see section 5.3). The usual dose is one 50 mg tablet taken twice a day (Galvus® brand), although sometimes only one dose a day is needed depending on what other medicines you are taking. Clinical experience in patients with NYHA functional class III treated with vildagliptin is still limited and results are inconclusive (see section 5.1).There is no experience of vildagliptin use in clinical trials in patients with NYHA functional class IV and therefore use is not recommended in these patients.Skin lesions, including blistering and ulceration have been reported in extremities of monkeys in non-clinical toxicology studies (see section 5.3). Patients are advised to follow a strict diet and exercise regimen along with this medicine for the best possible effect. Get info of suppliers, manufacturers, exporters, traders of Vildagliptin for buying in India. Flaking skin, peeling skin, scabs and tail sores with correlating histopathological changes were noted at doses ≥ 20 mg/kg/day (approximately 3 times human AUC exposure at the 100 mg dose). One side is debossed with “NVR”, and the other side with “FB”.Vildagliptin is indicated in the treatment of type 2 diabetes mellitus in adults:- in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance.- metformin, in patients with insufficient glycaemic control despite maximal tolerated dose of monotherapy with metformin,- a sulphonylurea, in patients with insufficient glycaemic control despite maximal tolerated dose of a sulphonylurea and for whom metformin is inappropriate due to contraindications or intolerance,- a thiazolidinedione, in patients with insufficient glycaemic control and for whom the use of a thiazolidinedione is appropriate.- a sulphonylurea and metformin when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control.Vildagliptin is also indicated for use in combination with insulin (with or without metformin) when diet and exercise plus a stable dose of insulin do not provide adequate glycaemic control.When used as monotherapy, in combination with metformin, in combination with thiazolidinedione, in combination with metformin and a sulphonylurea, or in combination with insulin (with or without metformin), the recommended daily dose of vildagliptin is 100 mg, administered as one dose of 50 mg in the morning and one dose of 50 mg in the evening.When used in dual combination with a sulphonylurea, the recommended dose of vildagliptin is 50 mg once daily administered in the morning. All the risks and benefits should be discussed with the doctor before taking this medicine.
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