The more I learned, the more I realized I needed to walk away from the prescription medications. In the mid-1990s, aromatase inhibitors with much greater specificity for the aromatase enzyme were developed, which produced no clinically relevant suppression of cortisol or aldosterone. The ongoing adjuvant trials have several basic designs: some compare 5 years of adjuvant tamoxifen with an aromatase inhibitor; others look at the use of sequential therapy with tamoxifen and an aromatase inhibitor; and the last group studies tamoxifen followed by an aromatase inhibitor The aromatase inhibitors have proven to be very active drugs in the treatment of hormone receptor-positive breast cancer. There were significantly more patients with ER/PR unknown tumors in the TARGET trial. Aromatase inhibitors (AIs), like arimidex, aromasin and femara, are also used to help fight cancer cell regrowth. Along with these choices, some women choose to add natural supplements to their health care regimen. Some side effects are mild while others are more severe. These drugs work to block cell receptors like estrogen and progesterone in breast cancers that are hormone receptor positive. The table below gives you a summary of some of the most common possible side effects of the different hormonal therapy medicines so you can do a general side-by-side comparison. Several studies are also evaluating the benefits of sequential administration of tamoxifen and an aromatase inhibitor.Although several trials are in progress, there are currently few data comparing the clinical efficacy of the third-generation aromatase inhibitors. Some of the more serious side effects of Tamoxifen include blood clots, stroke, endometrial cancer and memory loss.Aromatase inhibitors (AIs), like arimidex, aromasin and femara, are also used to help fight cancer cell regrowth. I was unwilling and unable to continue suffering the physical side effects and contacted the doctor once again. Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer. I am not a medical professional and do not claim to be. Rose Several additional trials are under way comparing aromatase inhibitors in a variety of clinical settings. The most prevalent side effect was severe bone and join pain. The aromatase inhibitors prevent conversion of adrenal androgens into estrogens via the inhibition of the cytochrome P-450-dependent enzyme aromatase. This side effect can be serious enough to … Given their efficacy and lack of significant side effects, the aromatase inhibitors have largely replaced megestrol as second-line hormonal therapy for metastatic breast cancer. Side effects of aromatase inhibitors Aromatase inhibitors tend to cause fewer serious side effects than tamoxifen, such as blood clots, stroke, and endometrial cancer.
I hope doctors will begin to listen to their patients and register their concerns. Studies have shown no impact on cortisol or aldosterone levels in patients being treated with 3–10 mg/day anastrozole for up to 3 months Only one study has compared the clinical efficacy of third-generation aromatase inhibitors. While the agents are associated with slightly improved survival outcomes when compared to tamoxifen alone, bone and musculoskeletal side effects are substantial and often lead to discontinuation of therapy. In the first-line setting, large Phase III trials have demonstrated that anastrozole and letrozole are equivalent or superior to tamoxifen in women with metastatic disease. Future trials must determine whether these differences are clinically important.Thank you for sharing this Clinical Cancer Research article.NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. At that time, I was 56 years old, but felt more like I was in my mid 80s. For women who are considering extending treatment with an aromatase inhibitor to a full ten years, these relatively modest benefit in disease free survival will be weighed with the side effects of AIs including bone loss (osteoporosis and bone fracture), joint and muscle pain, hot flashes and night sweats, and sexual effects. Further information is needed to determine whether or not aromatase inhibitors should be used in place of tamoxifen. Every day, I felt worse than the day before. These third-generation inhibitors include the steroidal drug exemestane and the nonsteroidal drugs letrozole, anastrozole, and vorozole.
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