Acarbose treatment resulted in a significant increase in the incidence of renal tumors (adenomas and adenocarcinomas) and benign Leydig cell tumors. Some patients may benefit from further increasing the dosage to 100 mg t.i.d. In both of these studies, the increased incidence of renal tumors found in the original studies did not occur. Use acarbose as ordered by your doctor. There is little if any clinically significant interaction between Acarbose and metformin. The maximum recommended dose for patients >60 kg is 100 mg t.i.d.Sulfonylurea agents or insulin may cause hypoglycemia. It is not known whether this drug is excreted in human milk. The safety … If you think there has been an overdose, call your poison control center or get medical care right away. If strongly distressing symptoms develop in spite of adherence to the diabetic diet prescribed, the doctor must be consulted and the dose temporarily or permanently reduced.Unlike sulfonylureas or insulin, an overdose of Acarbose will not result in hypoglycemia. It does not appear to directly alter insulin resistance, but may lower postprandial plasma insulin levels. Interactions Found. Generic Name : Acarbose Pronunciation : ak-ar-bos Latest prescription information about Acarbose. However, these symptoms tend to subside with continued treatment and adherence to an appropriate diet. 2019 Dec 11;8(12):635. doi: 10.3390/antiox8120635.Oboh G, Ogunsuyi OB, Adegbola DO, Ademiluyi AO, Oladun FL.Biomed J.
The antihyperglycemic action of Acarbose results from a competitive, reversible inhibition of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase enzymes. Springer Indications and Usage for Acarbose. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Improved metabolic control appears to delay or prevent long term vascular complications of diabetes, and indeed, acarbose appeared to inhibit development of such complications in preliminary animal studies, but this finding requires confirmation in clinical studies. Indications and Usage for Clonidine Injection. Hypoglycemia does not occur in patients receiving metformin alone under usual circumstances of use, and no increased incidence of hypoglycemia was observed in patients when Acarbose was added to metformin therapy. If the prescribed diet is not observed, the intestinal side effects may be intensified. If you have questions about side effects, call your doctor. In diabetic patients, this enzyme inhibition results in a delayed glucose absorption and a lowering of postprandial hyperglycemia.Because its mechanism of action is different, the effect of Acarbose to enhance glycemic control is additive to that of sulfonylureas, insulin or metformin when used in combination. Acarbose tablets should be started at a low dose, with gradual dose escalation as described below, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. Acarbose given in combination with a sulfonylurea or insulin may cause a further lowering of blood glucose and may increase the potential for hypoglycemia.
If elevated transaminases are observed, a reduction in dosage or withdrawal of therapy may be indicated, particularly if the elevations persist.Monitoring glycemic control with 1,5-AG assay is not recommended as measurements of 1,5-AG are unreliable in assessing glycemic control in patients taking Acarbose. **The 300 mg t.i.d. to 50 mg t.i.d. It is a generic sold in Europe and China as Glucobay , in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase .
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