In some cases, although not all, these urges were reported to have stopped when the dose was reduced or the medication was discontinued. Amantadine hydrochloride can exacerbate mental problems in patients with a history of psychiatric disorders or substance abuse. If your symptoms are severe, call 911 or go to the nearest emergency room right away. Electrocardiographic monitoring may be required after ingestion, since malignant tachyarrhythmias can appear after overdose.Care should be exercised when administering adrenergic agents, such as isoproterenol, to patients with an amantadine hydrochloride overdose, since the dopaminergic activity of amantadine hydrochloride has been reported to induce malignant arrhythmias.The blood electrolytes, urine pH and urinary output should be monitored.
Amantadine Hydrochloride Tablets should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit. The mean ± SD maximum plasma concentration was 0.22 ± 0.03 mcg/mL (range: 0.18 to 0.32 mcg/mL). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system (CNS) pathology.The management of NMS should include: 1) intensive symptomatic treatment and medical monitoring, and 2) treatment of any concomitant serious medical problems for which specific treatments are available.
The patient should be observed for the possible development of arrhythmias and hypotension; if required, appropriate antiarrhythmic and antihypotensive therapy should be given. Because patients may not recognize these behaviors as abnormal it is important for prescribers specifically ask patients or their caregivers about the development of new or increased gambling urges, sexual urges, uncontrolled spending or other urges while being treated with amantadine hydrochloride. It has very little or no activity against influenza B virus isolates. Amantadine Hydrochloride Tablets should be held constant at 100 mg daily or twice daily while the daily dose of levodopa is gradually increased to optimal benefit.When Amantadine Hydrochloride Tablets are added to optimal well-tolerated doses of levodopa, additional benefit may result, including smoothing out the fluctuations in improvement which sometimes occur in patients on levodopa alone. © Wort & Bild Verlag Konradshöhe GmbH & Co. KG - A quantitative relationship between the Drug Resistance: Influenza A variants with reduced Mechanism of Action: Parkinson's Disease- The mechanism of action of amantadine hydrochloride in the treatment of Parkinson's disease and drug-induced extrapyramidal reactions is not known. © 2005-2020 Healthline Media a Red Ventures Company.
Alternatively, temporary discontinuation of Amantadine Hydrochloride Tablets for several weeks , followed by reinitiation of the drug, may result in regaining benefit in some patients. The apparent oral clearance was 0.28 ± 0.11 L/hr/kg (range: 0.14 to 0.62 L/hr/kg). In addition, each tablet contains the following inactive ingredients: hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, purified water, sodium starch glycolate and FD&C Yellow No. This drug comes with risks if you don’t take it as prescribed.If you think you’ve taken too much of this drug, call your doctor or local poison control center. Patients who require a reduction in their usual dose of levodopa because of development of side effects may possibly regain lost benefit with the addition of Amantadine Hydrochloride Tablets.Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. The 100 mg dose is recommended for persons who have demonstrated intolerance of 200 mg of amantadine hydrochloride daily because of CNS or other toxicities.Prophylactic dosing should be started in anticipation of an influenza A outbreak and before or after contact with individuals with influenza A virus respiratory tract illness.Amantadine hydrochloride should be continued daily for at least 10 days following a known exposure.
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