Once adequate arrhythmia control is achieved, or if side effects become prominent, reduce amiodarone hydrochloride dose to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day. These data probably reflect an initial elimination of drug from well-perfused tissue (the 2.5- to 10-day half-life phase), followed by a terminal phase representing extremely slow elimination from poorly perfused tissue compartments such as fat.The considerable inter-subject variation in both phases of elimination, as well as uncertainty as to what compartment is critical to drug effect, requires attention to individual responses once arrhythmia control is achieved with loading doses because the correct maintenance dose is determined, in part, by the elimination rates. In some clinically hypothyroid amiodarone-treated patients, free thyroxine index values may be normal. The dose of MINIPRESS should be adjusted according to the patient's individual blood pressure response. During long-term treatment, a blue-gray discoloration of the exposed skin may occur. The inactive ingredients present are colloidal silicon dioxide, corn starch, lactose monohydrate, magnesium stearate, povidone, and D&C yellow No. 0185-0144-60 {* traditionalSignIn_signInButton *} If Evaluate continued need for antiarrhythmic.Increased digoxin concentration. It is usually taken once or twice a day. Pfizer would like to place cookies on your computer to customize our offerings to you via this website, to make information more readily accessible to you, and to make this website easier for you to use.
Maintenance Dose.
Prednisone 40 to 60 mg/day tapered over several weeks may be helpful in treating pulmonary toxicity.Postoperatively, occurrences of ARDS have been reported in patients receiving amiodarone hydrochloride therapy who have undergone either cardiac or noncardiac surgery. Dispense contents in a tight, light-resistant container as defined in the USP, with a child-resistant closure as required.This product’s label may have been updated.
{* createAccountButton *} It may cause severe and sometimes deadly side effects like lung, thyroid, or liver problems. Talk with your healthcare provider before you stop taking amiodarone hydrochloride tablets.Who should not take amiodarone hydrochloride tablets?Do not take amiodarone hydrochloride tablets if you:Before taking amiodarone hydrochloride tablets tell your doctor about all of your medical conditions, including if you:How should I take amiodarone hydrochloride tablets?Take your dose of amiodarone hydrochloride tablets the same way each time, either with or without food.What should I avoid while taking amiodarone hydrochloride tablets?“What are the possible side effects of amiodarone hydrochloride tablets?” What are the possible side effects of amiodarone hydrochloride tablets?Amiodarone hydrochloride tablets can cause serious side effects, including:“What is the most important information I should know about amiodarone hydrochloride tablets?”How should I store amiodarone hydrochloride tablets?Keep amiodarone hydrochloride tablets and all medicines out of the reach of children.General information about the safe and effective use of amiodarone hydrochloride tabletsWhat are the ingredients in amiodarone hydrochloride tablets? Although patients usually respond well to vigorous respiratory therapy, in rare instances the outcome has been fatal.Asymptomatic elevations of hepatic enzyme levels are seen frequently, but amiodarone hydrochloride can cause life-threatening hepatic injury. Neither amiodarone hydrochloride nor its metabolite is dialyzable.Amiodarone hydrochloride tablets are an antiarrhythmic drug, available for oral administration as yellow, scored tablets containing 200 mg of amiodarone hydrochloride. Plasma concentrations with chronic dosing at 100 to 600 mg/day are approximately dose proportional, with a mean 0.5 mg/L increase for each 100 mg/day. Maintenance Dose. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, amiodarone exerts a noncompetitive antisympathetic action. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a class III effect. In the rabbit, 75 mg/kg/day (approximately 2.7 times the maximum recommended human maintenance dose*) caused abortions in greater than 90% of the animals.
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