We're a charity and we couldn't continue our work without your help.We're taking the nation's craftiest fundraiser online.Tips, guidance and blogs to support your organisation.Explains what antipsychotics are used for, how the medication works, possible side effects and information about withdrawal.This page contains comparison tables, presenting all antipsychotics by:(For information about what the half-life means and why it matters, see our page on This information was published in 2016. In a West Australian study of an adult community psychiatric service, over half of people with severe mental illness had metabolic syndrome.It is estimated that the risk of diabetes in the people with psychosis is 2–6 times higher than the rest of the population, depending on age (the young have accelerated risk rates). 424348) in England and Wales. Depending on the sample, impaired fasting glucose was found in up to 41% of those with severe psychiatric illness. Given The percentages in the list below represent the typical long-term weight gain associated with each atypical antipsychotic drug.
Antipsychotic medicines are mainly used to treat mental health conditions such as schizophrenia and other psychoses, agitation, severe anxiety, mania and violent or dangerously impulsive behaviour.They are also used to treat nausea and vomiting, intractable hiccough and for the management of pain and associated restlessness in palliative care.Antipsychotics work by increasing or reducing the effects of natural chemicals (called neurotransmitters) in the brain, including:These neurotransmitters regulate numerous aspects of behaviour including:Antipsychotics can be classified by their chemical structure, but can also be distinguished by their pharmacology (their action at different neurotransmitters receptors) and by their clinical properties.Older antipsychotics were first developed in the 1950s and act primarily to reduce the effect of dopamine in the brain.Newer antipsychotics were developed from the 1970s onwards.
To view this licence, visit The newer antipsychotics are less likely to cause movement disorders as a side effect than older antipsychotics, although they may still cause movement disorders when used at higher doses.The following newer antipsychotics are licensed for use in the UK:Older antipsychotics licensed for use in the UK include:As with all medicines, antipsychotics can produce side effects in some people.The most common include movement disorders (referred to as extrapyramidal side effects) such as:Rarely, antipsychotics may cause more serious side effects such as:Antipsychotics can also increase the risk of stroke in elderly people with dementia and in any patient with pre-existing risk factors for stroke.This is not a complete list of all of the known side effects of antipsychotics - full guidance on prescribing and use, including information on possible side effects of antipsychotics is provided in the summary of product characteristics (SPC) for health professionals and the patient information leaflet (PIL) that should accompany the medicine for patients.There is a clear increased risk of stroke and a small increased risk of death when antipsychotics are used in elderly people with dementia.Only 1 antipsychotic, risperidone (Risperdal), is licensed for treatment of dementia-related behavioural disturbances in the UK and then only specifically for short-term (up to 6 weeks) treatment of persistent aggression in moderate to severe Alzheimer’s dementia which is unresponsive to non-pharmacological approaches (ie those that do not involve use of medicines) and where there is risk of harm to the patient or others.The risperidone (Risperdal) licence for the short-term treatment of persistent aggression in Alzheimer’s dementia was granted in 2008. 219830) and a registered company (no. This publication is available at https://www.gov.uk/government/publications/antipsychotic-medicines-licensed-products-uses-and-side-effects/antipsychotic-medicines
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