” Both dosage and frequency should be tapered gradually (see section 4.2).The administration of Isosorbide mononitrate causes a decrease of ERPF (Effective Renal Plasma Flow) in cirrhotic patients and should be used with caution.Hypotension induced by nitrates may be accompanied by paradoxical bradycardia and increased angina.Severe postural hypotension with light-headedness and dizziness is frequently observed after the concomitant consumption of alcohol.Eumon 40XL tablets contain lactose, and therefore patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.The hypotensive effects of nitrates are potentiated by concurrent administration of phosphodiesterase type-5 inhibitors (e.g. If methaemoglobinaemia occurs, treat with supplemental oxygen and methylene blue. Reports suggest that concomitant administration of Isosorbide Mononitrate may increase the blood level of dihydroergotamine and its hypertensive effect.Concomitant use with the soluble guanylate cyclase stimulator, riociguat, can cause hypotension and is contraindicated (see section 4.3).No data have been reported which would indicate the possibility of adverse effects resulting from the use of isosorbide mononitrate in pregnancy.The safety and efficacy of Eumon 40 XL modified release tablets during pregnancy has not been established. Before you begin talking with MT about his medications, he tells you that he has been experiencing a headache that he rates 8 out of 10 on a pain scale for the past couple of days. The dose may be increased to two tablets (80 mg), the whole dose to be given together (dose range 30mg to 120mg.) Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Nitrates can dilate epicardial coronary arteries including atherosclerotic stenoses.The cellular mechanism of nitrate-induced smooth muscle relaxation has become apparent in recent years. This cleavage requires the presence of sulphydryl groups, which apparently come from the amino acid cysteine. Hypotension including postural hypotension, with symptoms such as dizziness, fatigue and nausea has occasionally been reported. Nitric oxide undergoes further reduction to nitrosothiol by further interaction with sulphydryl groups. Unlike isosorbide dinitrate, ISMN does not undergo first-pass hepatic metabolism and bioavailability is 100%. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. Attenuation of effect (tolerance) has occurred in some patients being treated with sustained release preparations. The dose can be titrated to minimise the possibility of headache by initiating treatment with lesser dose for the first two to four days. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.If you experience any other symptoms which you think may be due to the medicine, please speak with your doctor or pharmacist for further advice.Never take more than the prescribed dose. Very occasionally the matrix may pass through the gastrointestinal tract without disintegrating and be found inside the stool, but all active substance has been releasedThe tablets should not be chewed or crushed and should be swallowed with half a glass of fluid.Hypersensitivity to the active substance or to any of the excipients listed in section 6.1.
Isosorbide mononitrate should only be used in pregnancy if, in the opinion of the physician, the possible benefits of treatment outweigh the possible hazardsThe safety and efficacy of Eumon 40 XL modified release tablets during lactation has not been established. Uncommonly, collapse may occur (sometimes accompanied by bradyarrhythmia, bradycardia and syncope). Take them to your local pharmacy which will dispose of them for you.If you have any questions about this medicine ask your pharmacist.See if you are eligible for a free NHS flu jab today.Hello, just wanted to post some hopefully helpful info for those who have struggled with PVC's and found little help from the Medical Community. Hypertrophic obstructive cardiomyopathy, constrictive pericarditis, cardiac tamponade, aortic/mitral valve stenosis, hypovolaemia closed-angle glaucoma, severe anaemia, conditions causing raised intracranial pressure e.g following head trauma, cerebral haemorrhage.Eumon 40 XL should not be given to patients with a known sensitivity to nitrates.Concomitant use with the soluble guanylate cyclase stimulator, riociguat, can cause hypotension and is contraindicated (see section 4.5).Eumon 40 XL modified release tablets are not indicated for relief of acute anginal attacks. Worth it. There have been isolated reports of myalgia.Drowsiness, diarrhoea or vomiting may occur.
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