This review will focus on AI-associated musculoskeletal toxicity, including typical symptoms, potential etiologies, and strategies for management of the side effects.
Conclusion: We conclude that aromatase inhibitor induced musculoskeletal syndrome is a significant issue for Australian women and is an important reason for treatment discontinuation. Aromatase inhibitors (AIs) are a class of drugs widely used in the treatment of estrogen sensitive breast and ovarian cancer. Their mechanism of action consists in inhibiting the aromatase enzyme which is responsible for the conversion of testosterone to estradiol and androstenedione to estrogen.
We aimed to understand the manifestations and impact of this syndrome in the Australian breast cancer community, and strategies used for its management.
Ideally, the symptoms should be prevented or adequately … Aromatase inhibitors are widely used as adjuvant therapy in postmenopausal women with hormone receptor-positive breast cancer. The AIs of third generation, including anastrazole, letrozole and … Anti-inflammatories, paracetamol (acetaminophen) and yoga were most successful in relieving symptoms in each of the respective categories. Conclusion: We conclude that aromatase inhibitor induced musculoskeletal syndrome is a significant issue for Australian women and is an important reason for treatment discontinuation.
SNPs are associated with musculoskeletal pain. Conclusion: We conclude that aromatase inhibitor induced musculoskeletal syndrome is a significant issue for Australian women and is an important reason for treatment discontinuation. Twenty-seven percent had discontinued treatment for any reason and of these, 68 % discontinued because of the musculoskeletal syndrome. Lombard, Janine M. ; Zdenkowski, Nicholas ; Wells, Kathy ; Beckmore, Corinna ; Reaby, Linda ; Forbes, John F ; Chirgwin, Jacquie. Anti-inflammatories, paracetamol (acetaminophen) and yoga were most successful in relieving symptoms in each of the respective categories.
AI are often associated with significant joint and muscular symptoms; symptoms that are commonly referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS). Aromatase inhibitor induced musculoskeletal syndrome (AIMSS) in Australian women with early breast cancer: An Australia and New Zealand Breast Cancer Trials Group (ANZBCTG) survey of members of the Breast Cancer Network Australia (BCNA) [abstract]. Evidence for effective treatments is lacking. Results: Aromatase inhibitor induced musculoskeletal syndrome was reported by 302 (82 %) of 370 respondents. Eighty-one percent had used at least one intervention from the following three categories to manage the syndrome: doctor prescribed medications, over-the-counter/complementary medicines or alternative/non-drug therapies. Aromatase Inhibitors (AI) are widely used for the adjuvant treatment of hormone receptor positive breast cancers in the post-menopausal population.
Aromatase inhibitor induced musculoskeletal syndrome: a significant problem with limited treatment optionsAromatase inhibitor induced musculoskeletal syndrome: a significant problem with limited treatment optionsAromatase inhibitor induced musculoskeletal syndrome: a significant problem with limited treatment options Women use a variety of interventions to manage this syndrome; however, their efficacy appears limited.AB - Background: Aromatase inhibitor induced musculoskeletal syndrome is experienced by approximately half of women taking aromatase inhibitors, impairing quality of life and leading some to discontinue treatment.
The online questionnaire included 45 questions covering demographics, aromatase inhibitor use, clinical manifestations and risk factors for the aromatase inhibitor musculoskeletal syndrome, reasons for treatment discontinuation and efficacy of interventions used. This is the first systematic review to consider the evidence for all pharmacological and non-pharmacological interventions in the treatment of AIMSS, including physical therapy, acupuncture and complementary therapies.We use cookies to help provide and enhance our service and tailor content and ads.
AIMSS adversely impacts health-related quality of life of many patients, and reduces AI compliance. 1 Introduction. Women use a variety of interventions to manage this syndrome; however, their efficacy appears limited.T1 - Aromatase inhibitor induced musculoskeletal syndromeT2 - a significant problem with limited treatment optionsN2 - Background: Aromatase inhibitor induced musculoskeletal syndrome is experienced by approximately half of women taking aromatase inhibitors, impairing quality of life and leading some to discontinue treatment.
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