It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com.
The study is created by eHealthMe based on reports of 60 people who take Diflucan and Atorvastatin calcium from the FDA, and is updated regularly. Eur J Drug Metab Pharmacokinet. Common side effects include joint pain, diarrhea, heartburn, nausea, and muscle pains.
Carefully weigh the potential benefits and risk of combined therapy. All rights reserved. Dosage of drugs is not considered in the study. Elsevier Science
Atorvastatin (Lipitor) Lovastatin (Mevacor) Simvastatin (Zocor) Avoid lovastatin and simvastatin11, 21, 22. This study aimed to predict pharmacokinetic DDIs possibly causing atorvastatin-induced rhabdomyolysis using Physiologically Based Pharmacokinetic (PBPK) Modelling. Unable to load your delegates due to an error Eur J Clin Pharmacol 2005 Feb;60(12):905-7.
Thereafter, we predicted the exposure changes of atorvastatin and atorvastatin lactone originating from the case reports of atorvastatin-induced rhabdomyolysis using the refined models. Elsevier Science Drug interactions are reported among people who take Diflucan and Atorvastatin calcium together. Unable to load your collection due to an error Firstly, we refined the PBPK models of atorvastatin and atorvastatin lactone for predicting the DDIs with CYP3A4 and OATP inhibitors. Fluvastatin is an oral, cholesterol-lowering drug.It belongs to a class of drugs called HMG-CoA reductase inhibitors, commonly called "statins. Some reports may have incomplete information.Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. In this study, concurrent atorvastatin administration decreased the total plasma clearance of midazolam by 33% (0.27 vs. 0.18 l‐kg.h −1) and increased the area under the curve by 40% (629 vs. 889 ng‐h.ml −1).
Epub 2019 Aug 1.Yao Y, Toshimoto K, Kim SJ, Yoshikado T, Sugiyama Y.Drug Metab Dispos. Though the statin-induced rhabdomyolysis is not common during statin therapy, its incidence will significantly increase due to pharmacokinetic drug-drug interactions (DDIs) with inhibitor drugs which inhibit atorvastatin's and its lactone's metabolism and hepatic uptake. The atorvastatin lactone PBPK model was validated by comparing the simulated pharmacokinetics profile of atorvastatin lactone to the observed clinical data [16,17,, , ]. May be combined with bile acid–binding resin. * Approximation only. Consequently, clinicians should be aware of necessary dose adjustment of atorvastatin being used with these four inhibitor drugs. The trial design and characteristics of subjects were based on the reported study [16,26]. The study is based on fluconazole and atorvastatin calcium (the active ingredients of Diflucan and Atorvastatin calcium, respectively), and Diflucan and Atorvastatin calcium (the brand names).
Clipboard, Search History, and several other advanced features are temporarily unavailable. Published by Elsevier Masson SAS.. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Thus, the quantitative analysis of DDIs of atorvastatin and its lactone with cytochrome P450 3A4 (CYP3A4) and organic anion-transporting polypeptide (OATP) inhibitors is of great importance. Please enable it to take advantage of the complete set of features! 2018 Jul;46(7):924-933. doi: 10.1124/dmd.117.079210. The simulation results show that pharmacokinetic DDIs of atorvastatin and its lactone with fluconazole, palbociclib diltiazem and cyclosporine are significant. 1 Absolute bioavailability is approximately 14%. Epub 2013 Dec 20.Clin Pharmacol Ther. 1 Evening administration associated with a decrease in the extent of absorption; 1 however, antilipemic activity … generic drugs) are not considered. Atorvastatin and its lactone form metabolite are reported to be associated with statin-induced myopathy (SIM) such as myalgia and life-threatening rhabdomyolysis. Name must be less than 100 characters This site needs JavaScript to work properly.
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