Azithromycin capsules are for oral administration only. • Since the liver is the principal route of elimination for azithromycin, the use of azithromycin should be undertaken with caution in patients with significant hepatic disease. Nursing may be resumed thereafter.In fertility studies conducted in rat, reduced pregnancy rates were noted following administration of azithromycin.
• Penicillin is usually the first choice for treatment of pharyngitis/tonsillitis due to
folliculitis, cellulitis, erysipelasConsideration should be given to official guidance on the appropriate use of antibacterial agents.
• - With electrolyte disturbance, particularly in cases of hypokalaemia and hypomagnesaemia Continue typing to refine. • The total dose is 1500 mg, administered as 500 mg once daily for 3 days.
When suggestions are available use up and down arrows to review and ENTER to select. Exacerbations of the symptoms of myasthenia gravis and new onset of myasthenia syndrome have been reported in patients receiving azithromycin therapy (see section 4.8). The safety of azithromycin has not been confirmed with regard to the use of the active substance during pregnancy. The molecule is constructed by adding a nitrogen atom to the lactone ring of erythromycin A.The chemical name of azithromycin is 9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A. Exacerbations of the symptoms of myasthenia gravis and new onset of myasthenia syndrome have been reported in patients receiving azithromycin therapy (see section 4.8).
Binding to serum proteins varies according to plasma concentration and ranges from 12% at 0.5 microgram/ml up to 52% at 0.05 microgram azithromycin/ml serum. The tablets should be taken with ½ glass of water.Hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any of the excipient listed in section 6.1. • Reporting suspected adverse reactions after authorisation of the medicinal product is important. Azithromycin Capsules are for oral administration only.The use of azithromycin is contraindicated in patients with hypersensitivity to azithromycin, erythromycin, any macrolide or ketolide antibiotic, or to any of the excipients (listed in Section 6.1). Concomitant administration of macrolide antibiotics, including azithromycin, with P-glycoprotein substrates such as digoxin and colchicine, has been reported to result in increased serum levels of the P-glycoprotein substrate. Phospholipidosis has been observed to a similar extent in the tissues of neonatal rats and dogs. Hepatic cytochrome P450 induction or inactivation via cytochrome-metabolite complex does not occur with azithromycin.Due to the theoretical possibility of ergotism, the concurrent use of azithromycin with ergot derivatives is not recommended (see section 4.4 Special warnings and special precautions for use).Pharmacokinetic studies have been conducted between azithromycin and the following drugs known to undergo significant cytochrome P450 mediated metabolism.Co-administration of atorvastatin (10 mg daily) and azithromycin (500 mg daily) did not alter the plasma concentrations of atorvastatin (based on a HMG CoA-reductase inhibition assay).In a pharmacokinetic interaction study in healthy volunteers, no significant effect was observed on the plasma levels of carbamazepine or its active metabolite in patients receiving concomitant azithromycin.In a pharmacokinetic study investigating the effects of a single dose of cimetidine, given 2 hours before azithromycin, on the pharmacokinetics of azithromycin, no alteration of azithromycin pharmacokinetics was seen.In a pharmacokinetic interaction study, azithromycin did not alter the anticoagulant effect of a single 15-mg dose of warfarin administered to healthy volunteers. • - With clinically relevant bradycardia, cardiac arrhythmia or severe cardiac insufficiency.
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