Cancer-related outcomes included incidence of primary breast cancer and recurrence, as well as effects on estrogen responsive tissues. However, other studies indicate that methanol extracts of C. racemosa contain substances that bind to estrogen receptors.Several systematic meta-analyses, including a Cochrane review, have concluded that evidence is very weak to support efficacy of black cohosh in ameliorating menopausal symptoms.Black cohosh was compared with tibolone treatment in 125 women with endometriosis experiencing menopausal symptoms induced by postoperative gonadotropin-releasing hormone agonist therapy.
Consult your healthcare provider for guidance.Black cohosh should be kept sealed and stored at room temperature.
Its irregular-shaped leaflets have toothed edges. Some of these third-party testing organizations include United States Pharmacopeia (USP) and ConsumerLab.Additionally, black cohosh is often sold in blends containing other herbal supplements, including:According to existing evidence, there do not appear to be any complications associated with stopping black cohosh suddenly, nor are there any known withdrawal symptoms.If you have any concerns about stopping black cohosh, consult a healthcare provider.It’s unknown whether it’s possible to overdose on black cohosh. Improvements in vasomotor and physical domains of life quality were also observed.
Data from clinical trials indicated a reduction in risk for primary breast cancer (adjusted odds ratio [OR], 0.47 [95% CI, 0.27 to 0.82]) and breast cancer recurrence (OR, 0.75 [95% CI, 0.63 to 0.89]). One observational study evaluating effects on quality of life (n=788) also identified no significant effects associated with the use of black cohosh.Three RCTs were identified in a systematic review of studies (published over a 20-year period from 1996 to 2016) investigating the use of black cohosh for anxiety or depression. It has been suggested that black cohosh acts directly on the hypothalamus to reduce gonadotropin-releasing hormone release and not via a direct effect on the pituitary.Therapeutic action in peripheral arterial disease has been noted as a result of peripheral vasodilation and increased blood flow.Black cohosh has been identified as having anti-HIV activity,Black cohosh extract is generally standardized to 2.5% of triterpene glycosides (ie, 1 mg/dose). The plant has been used in Europe since the 17th century to treat joint pain, neuralgia, and pain in pregnancy and labor. Bernacki DT, Bryce SM, Bemis JC, Dertinger SD, Witt KL, Smith-Roe SL. If you’re taking either of the medications listed above or have any concerns about black cohosh and other medications, consult a healthcare provider before taking it.Additionally, because one of the most severe side effects of black cohosh is liver damage, you should be cautious of taking black cohosh in combination with any other supplements or medications that may damage your liver. Liver transplant was also more frequent with toxicity from non-bodybuilding supplements (13%) than with conventional medications (3%) (In addition to hepatotoxicity, 3 cases related to cardiac and circulatory disorders, 1 case of convulsions, and 1 case of seizures have been reported.Whether black cohosh has effects on endometrial tissue similar to that of hormone replacement therapies is controversial. This is only a brief summary of general information about this product.
There is a lack of consensus regarding whether black cohosh is useful for managing some symptoms of menopause.
Additionally, cytotoxic effects on human cervical carcinoma cells have been reported. Healthline Media does not provide medical advice, diagnosis, or treatment. There are concerns regarding rare, but serious, hepatotoxicity.Overdose of black cohosh may cause nausea, vomiting, dizziness, nervous system and visual disturbances, reduced pulse rate, and increased perspiration. Select one or more newsletters to continue.
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