Bigelow RL, Williams BJ, Carroll JL, Daves LK, Cardelli JA.Breast Cancer Res Treat. Natural product compound collections have proven an effective way to access chemical diversity and recent findings have identified phenolic, coumarin, and polyamine natural products as atypical chemotypes that inhibit carbonic anhydrases (CAs).
1955 Nov;40(5 Pt 2):129-36. doi: 10.1016/0002-9394(55)91845-6.J Clin Invest. Gene knockdown of CAXII in the human breast cancer cell line MDA-MB-231 resulted in decreased invasion and migration by interfering with the p38 MAPK pathway. 2009 Jul;85(1):1-30. doi: 10.1016/j.eplepsyres.2009.02.017. CAXII knockdown also decreased the expression of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA), but increased tissue inhibitor of metalloproteinases (TIMP)-2 and plasminogen activator inhibitor (PAI)-1 expression. Unable to load your collection due to an error Carbonic anhydrase inhibitors reduce the activity of carbonic anhydrase, an enzyme responsible for catalyzing the reaction between carbon dioxide and water into carbonic acid and then bicarbonate. 1955 Jun 15;11(6):234-5. doi: 10.1007/BF02160475.Acta Med Scand. Carbonic anhydrase (CA) XII, an extracellular enzyme involved in the regulation of the microenvironment acidity and tumor malignant phenotype, was originally identified as a protein overexpressed in some types of cancers, including breast cancer. Unable to load your collection due to an error
Additionally, like the other carbonic anhydrases, CDCA makes the reaction go almost as fast as the diffusion rate of its substrates, and it can be inhibited by sulfonamide and sulfamate derivatives. Results also showed that CAXII knockdown may decrease anchorage-independent growth and cell growth by inhibiting CDK6 and cyclin D1 expression. Epub 2009 Apr 29.CNS Neurosci Ther. CA enzymes are implicated as targets of variable drug therapeutic classes and the discovery of selective, drug-like CA inhibitors is essential. This reduces the resorption of bicarbonate from the proximal tubule in the kidneys, which causes a direct increase in bicarbonate excretion and mild increases in sodium, and potassium excretion. J Pharmacol Exp Ther. This site needs JavaScript to work properly. Epub 2007 Dec 25.Gene. Clipboard, Search History, and several other advanced features are temporarily unavailable.
2009 Sep;117(1):31-44. doi: 10.1007/s10549-008-0170-7. 1956 Mar 8;154(1):53-64. doi: 10.1111/j.0954-6820.1956.tb14299.x.Zhao H, Carney KE, Falgoust L, Pan JW, Sun D, Zhang Z.Prog Neurobiol. Please enable it to take advantage of the complete set of features! Epub 2016 Mar 8.Front Neurol. The actual mechanisms by which acetazolamide reduces symptoms of AMS, however, remain …
Furthermore, decreased invasive and migration ability of CAXII-knockdown cells were restored by an overexpression of CAXII. 1955 Nov;115(3):251-8. Taken together, these data suggested that CAXII may affect the capability of invasion and migration of MDA-MB-231 cells, which may be mediated through the p38 MAPK pathway. The mechanism of cadmium carbonic anhydrase (CDCA) is essentially the same as that of other carbonic anhydrases in its conversion of carbon dioxide and water into bicarbonate and a proton. 2016 Mar-May;138-140:19-35. doi: 10.1016/j.pneurobio.2016.02.002. Copyright 2010 Elsevier GmbH. It can be used as a diuretic or to treat glaucoma as it prevents excessive build up of aqueous humor. Epub 2017 Dec 14.Dinh TA, Sritharan R, Smith FD, Francisco AB, Ma RK, Bunaciu RP, Kanke M, Danko CG, Massa AP, Scott JD, Sethupathy P.Cell Rep. 2020 Apr 14;31(2):107509. doi: 10.1016/j.celrep.2020.03.073.Alfarouk KO, Ahmed SBM, Ahmed A, Elliott RL, Ibrahim ME, Ali HS, Wales CC, Nourwali I, Aljarbou AN, Bashir AHH, Alhoufie STS, Alqahtani SS, Cardone RA, Fais S, Harguindey S, Reshkin SJ.Cancers (Basel). Acetazolamide.
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