Look for the following side effects that can indicate your dog may be having a problem with Rovera or may have another medical problem:It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Rovera therapy. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.If additional pain medication is warranted after administration of the total daily dose of Carprovet, alternative analgesia should be considered. Each tablet size is packaged in bottles containing 60 or 180 tablets.Carprovet (carprofen) Flavored Tablets 25 mg, 60 tablets NDC 17033-359-60Carprovet (carprofen) Flavored Tablets 25 mg, 180 tablets NDC 17033-359-18Carprovet (carprofen) Flavored Tablets 75 mg, 60 tablets NDC 17033-360-60Carprovet (carprofen) Flavored Tablets 75 mg, 180 tablets NDC 17033-360-18Carprovet (carprofen) Flavored Tablets 100 mg, 60 tablets NDC 17033-358-60Carprovet (carprofen) Flavored Tablets 100 mg, 180 tablets NDC 17033-358-18For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call (866)933-2472.February 2017 L21I-DEC R-1702This summary contains important information about Carprovet.You should read this information before you start giving your dog Carprovet and review it each time the prescription is refilled. Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL after 2 weeks of treatment, returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment, and was 2.3 g/dL at the final 6-week evaluation. In these two field studies, dogs diagnosed with osteoarthritis showed statistically significant overall improvement based on lameness evaluations by the veterinarian and owner observations when administered carprofen at labeled doses.Separate placebo-controlled, masked, multicenter field studies confirmed the effectiveness of carprofen tablets for the control of postoperative pain when dosed at 2 mg/lb once daily in various breeds of dogs.
Some clinical signs were observed during field studies (n=297) which were similar for carprofen caplet- and placebo-treated dogs. 50386-1012-2, In both studies, the drug was well tolerated clinically by all of the animals. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years.Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Look for the following side effects that can indicate your dog may be having a problem with Carprofen Caplets or may have another medical problem:It is important to stop therapy and contact your veterinarian immediately if you think your dog has a medical problem or side effect from Carprofen Caplets therapy. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross pathologic examination. Concomitant use of carprofen with other anti-inflammatory drugs, such as other NSAIDs or corticosteroids, should be avoided because of the potential increase of adverse reactions, including gastrointestinal ulcerations and/or perforations. It is freely soluble in ethanol, but practically insoluble in water at 25°C.Carprofen is a non-narcotic, non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.The mechanism of action of carprofen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Carprofen is the nonproprietary designation for a substituted carbazole, 6-chloro-α-methyl-9H-carbazole-2-acetic acid.
The product vehicle served as control.There were no serious adverse events reported during clinical field studies with once daily oral administration of 2 mg/lb. Differences were not statistically significant. None of these animals showed clinical signs associated with laboratory value changes. Carprofen treatment was not associated with renal toxicity or gastrointestinal ulceration in well-controlled safety studies of up to ten times the dose in dogs. Most dogs will take Rovera Chewable Tablets right out of your hand or the tablet can be placed in the mouth. The product vehicle served as control.During investigational studies for the chewable tablet formulation, gastrointestinal signs were observed in some dogs. Since NSAIDs possess the potential to induce gastrointestinal ulcerations and/or gastrointestinal perforations, concomitant use of Carprofen and other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. Novox is the Vedco brand name for generic Carprofen and a generic equivalent to Rimadyl. Do not use in cats.All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy. Drug compatibility should be monitored closely in patients requiring additional therapy. Histologic exam of these areas revealed no evidence of ulceration, but did show minimal congestion of the lamina propria in 2 of the 5 dogs.In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen.
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