Advertisement. In one study, the adherence rate to statin therapy after 2 years was <40%.The consequences of nonadherence in post‐MI patients were well illustrated in retrospective analyses of the large‐scale Beta‐Blocker Heart Attack Trial (BHAT)Other studies also demonstrate that an adherence rate ≥80% is associated with better outcomes. COVID-19 is an emerging, rapidly evolving situation. 2019 Jun 7;11(11):3650-3667. doi: 10.18632/aging.102004.BMJ Open.
A new era in the treatment of heart failureEffect of chronic beta‐adrenergic receptor blockade in congestive cardiomyopathyProlongation of survival in congestive cardiomyopathy by beta‐receptor blockadeBeta‐1 and beta‐2 adrenergic‐receptors subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta‐1 receptor down‐regulation in heart failureComparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heartIncreased beta‐receptor density and improved hemodynamic response to catecholamine stimulation during long‐term metoprolol therapy in heart failure from dilated cardiomyopathySelective beta 1‐adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2‐adrenoceptors in human atrial myocardiumBeta 2‐adrenergic receptor antagonists protect against ventricular fibrillation: in vivo and in vitro evidence for enhanced sensitivity to beta 2‐adrenergic stimulation in animals susceptible to sudden deathSympatho‐adrenergic activation of the ischemic myocardium and its arrhythmogenic impactThe role of third‐generation beta‐blocking agents in chronic heart failure [published erratum appears in Long‐term betablocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: a double‐blind, randomized study of bucindolol versus placeboCarvedilol improves left ventricular function and symptoms in chronic heart failure: a double‐blind randomized studyDifferential effects of beta‐blockers in patients with heart failure: a prospective, randomized, double‐blind comparison of the long‐term effects of metoprolol versus carvedilolLong‐term effects of carvedilol in idiopathic dilated cardiomyopathy with persistent left ventricular dysfunction despite chronic metoprololComparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta‐analysisCarvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavengerCarvedilol inhibits reactive oxygen species generation by leukocytes and oxidative damage to amino acidsCarvedilol prevents remodeling in patients with left ventricular dysfunction after acute myocardial infarctionCarvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injuryCarvedilol inhibits vascular smooth muscle cell proliferationPossible involvement of stress‐activated protein kinase signaling pathway and Fas receptor expression in prevention of ischemia/reperfusion‐induced cardiomyocyte apoptosis by carvedilolNovel mechanisms in the treatment of heart failure: inhibition of oxygen radicals and apoptosis by carvedilolCarvedilol and its metabolites suppress endothelin‐1 production in human endothelial cell cultureComparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol or Metoprolol European Trial (COMET) randomized controlled trialCarvedilol improves renal hemodynamics in patients with chronic heart failureTreatment with carvedilol is associated with a significant reduction in microalbuminuria: a multicentre randomised studyAntihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta‐blocking agentsEfficacy of carvedilol in mild to moderate essential hypertension and effects on microalbuminuria: a multicenter, randomized, open‐label, controlled study versus atenololMetabolic and cardiovascular effects of carvedilol and atenolol in non‐insulin‐dependent diabetes mellitus and hypertension.
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