CAIs work by suppressing aqueous humor production. It may be necessary for you to use another medicine or to stop breast-feeding during treatment. Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging, rapidly evolving situation. 1991 May;145(5):942-8. doi: 10.1016/s0022-5347(17)38496-3.Am J Ophthalmol. Zonegran® (zonisamide) is an antiseizure drug chemically classified as a sulfonamide and unrelated to other antiseizure agents. All rights reserved.
Unable to load your collection due to an error Please enable it to take advantage of the complete set of features! Silverchair Information Systems Be sure you have discussed this with your doctor.Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. 1981 Mar;88(3):266-9. doi: 10.1016/s0161-6420(81)35040-4.Higashihara E, Nutahara K, Takeuchi T, Shoji N, Araie M, Aso Y.J Urol. Multiple serum chemical values were examined in 92 patients with chronic glaucoma who were treated with the carbonic anhydrase inhibitors (CAIs) acetazolamide or methazolamide, seeking relationships between serum composition and symptomatic side effects. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.The presence of other medical problems may affect the use of medicines in this class.
The empirical formula is C8H8N2O3S with a molecular weight of 212.23. doi: 10.1001/archopht.1977.04450080088009. This site needs JavaScript to work properly. Fatigue, skin rash, weight loss, depression, decreased sexual drive, kidney stones, and an altered taste for food (especially carbonated drinks) all have been noted as possible side effects. All rights reserved. 2007;7(9):849-54. doi: 10.2174/156802607780636735.Subcell Biochem. doi: 10.1001/archopht.1977.04450080088009. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Current pharmacological therapies for lowering the IOP in glaucoma include increasing aqueous humor outflow and suppression of aqueous humor production. However, studies in animals have shown that carbonic anhydrase inhibitors cause birth defects. Make sure you tell your doctor if you have any other medical problems, especially:Portions of this document last updated: Feb. 01, 2020Copyright © 2020 IBM Watson Health. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Patients who had this symptom complex were significantly more acidotic than those without it. Unable to load your delegates due to an error The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.Using medicines in this class with any of the following medicines is not recommended. 2014;75:349-59. doi: 10.1007/978-94-007-7359-2_17.Schmickl CN, Owens RL, Orr JE, Edwards BA, Malhotra A.BMJ Open Respir Res. 2020 Dec;35(1):733-743. doi: 10.1080/14756366.2020.1742117.Adv Ther. Of the 92 patients, 44 complained of a symptom-complex of malaise, fatigue, weight loss, depression, anorexia, and loss of libido, which we have Therefore, it may not be known whether they work exactly the same way they do in younger adults. 2018 Nov;26(7):909-920. doi: 10.1016/j.jsps.2018.01.005. Name must be less than 100 characters 2020 Apr;7(1):e000557.
The combination of zonisamide and carbonic anhydrase inhibitors or anticholinergics may increase your risk of heat stroke, which can be serious. Frequent urination may occur when these medications are first taken, but this is usually temporary and disappears with long term use. who were treated with the carbonic anhydrase inhibitors (CAIs) acetazolamide or methazolamide, seeking relationships between serum composition and symptomatic side effects. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER).
Aqueous humor secretion depends on the production of bicarbonate (HCO-3) from carbonic anhydrase II, an isoenzyme found in the non-pigmented ciliary body epithelium.
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