contraceptive pills may not protect you from pregnancy. There are no data available on the effect of clarithromycin on the ability to drive or use machines. Macrolides have been considered the drug of choice for group A streptococcal and pneumococcal infections when penicillin cannot be used. Clarithromycin is contraindicated in patients with known hypersensitivity to macrolides antibiotic drugs or to any of its excipients as listed in section 6.1. Do not refrigerate or freeze. The metabolite is less active than the parent compound for most organisms, including mycobacterium spp. Deaths have been reported in some such patients (see section 4.5). The potential for dizziness, vertigo, confusion and disorientation should be taken into account before patients drive or use machines.The most frequent and common adverse reactions related to clarithromycin therapy for both adult and paediatric populations are abdominal pain, diarrhoea, nausea, vomiting and taste perversion. Based on variable results obtained from studies in mice, rats, rabbits and monkeys, the possibility of adverse effects on embryofoetal development cannot be excluded. fluvastatin) can be considered. Patients taking itraconazole and clarithromycin concomitantly should be monitored closely for signs or symptoms of increased or prolonged pharmacologic effect.Both clarithromycin and saquinavir are substrates and inhibitors of CYP3A, and there is evidence of a bi-directional drug interaction. Slightly higher incidences of abnormal values were noted for patients who received 4000 mg daily for all parameters except White Blood Cell.Reports indicate that the ingestion of large amounts of clarithromycin can be expected to produce gastrointestinal symptoms. For benzodiazepines which are not dependent on CYP3A for their elimination (temazepam, nitrazepam, lorazepam), a clinically important interaction with clarithromycin is unlikely.There have been post-marketing reports of drug interactions and central nervous system (CNS) effects (e.g. A reduction in tolterodine dosage may be necessary in the presence of CYP3A inhibitors, such as clarithromycin in the CYP2D6 poor metabolizer population.When midazolam was co-administered with clarithromycin tablets (500 mg twice daily), midazolam AUC was increased 2.7-fold after intravenous administration of midazolam. The recommended daily dose of Clarithromycin 250mg/5ml Oral Suspension in children is given in the following table and is based on an approximate 7.5mg/ kg twice daily dosing regimen. fluvastatin) can be considered (see 4.5).In areas with a high incidence of erythromycin A resistance, it is especially important to take into consideration the evolution of the pattern of susceptibility to clarithromycin. It is highly potent against a wide variety of aerobic and anaerobic gram-positive and gram-negative organisms. rifampicin, phenytoin, carbamazepine, phenobarbital, St John's wort) may induce the metabolism of clarithromycin. Clarithromycin is a semi-synthetic derivative of erythromycin A.Clarithromycin is not the first choice for the therapy of pharyngitis. Necropsy of animals that died disclosed dark-reddish lungs in mice and about 25% of the rats; rats treated with 2197 mg/kg or more of a clarithromycin suspension were also noted to have a reddish - black substance in the intestines, probably because of bleeding. Open the pack - or packets - and mix the granules with a small amount of water to drink.There's also a liquid clarithromycin for children and people who find it difficult to swallow tablets.If you or your child are taking clarithromycin as a liquid, your pharmacist will usually make it up for you. *** A graduated syringe is provided with the bottle for use as a pipette. Keep taking the medicine, but tell your doctor if these side effects bother you or don't go away:Serious side effects are rare and happen in less than 1 in 1,000 people.In rare cases, it's possible to have a serious allergic reaction You could be having a serious allergic reaction and may need immediate treatment in hospital.These aren't all the side effects of clarithromycin.
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