For Dermatologic Use Only Not for Ophthalmic Use. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Because of a higher ratio of skin surface area to body mass, children are at a greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids. Clobetasol propionate gel should not be used in the treatment of rosacea or perioral dermatitis and it should not be used on the face, groin, or axillae.Carcinogenesis, Mutagenesis, Impairment of Fertilitytreatment should be limited to 2 consecutive weeks, and amounts greater than 50 g per week should not be used.Clobetasol propionate gel, 0.05% should not be used with occlusive dressings.We comply with the HONcode standard for trustworthy health information - Some corticosteroids have been shown to be teratogenic after dermal application to laboratory animals.Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Clobetasol, an analog of prednisolone, has a high degree of glucocorticoid activity and a slight degree of mineralocorticoid activity.Chemically, clobetasol propionate is (11ß,16ß)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione, and it has the following structural formula:Clobetasol propionate gel contains clobetasol propionate 0.5 mg/g in a gel base composed of carbomer 974P, propylene glycol, purified water, and sodium hydroxide.Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. Manifestations of adrenal suppression in children include low plasma cortisol levels, and an absence of response to ACTH stimulation. Contact dermatitis, including poison ivy or poison oak rash 4. Allergic contact dermatitis with corticosteroids is usually diagnosed by observing a If concomitant skin infections are present or develop, an appropriate antifungal or antibacterial agent should be used. Recovery of HPA axis function is generally prompt and complete upon discontinuation of topical corticosteroids. Clobetasol propionate has greater teratogenic potential than steroids that are less potent.Teratogenicity studies in mice using the subcutaneous route resulted in fetotoxicity at the highest dose tested (1 mg/kg) and teratogenicity at all dose levels tested down to 0.03 mg/kg.
They are therefore also at greater risk of adrenal insufficiency after withdrawal of treatment and of Cushing’s syndrome while on treatment. As with other highly active corticosteroids, therapy should be discontinued when control has been achieved.
The treatment of aphthous ulcer includes both over-the-counter products and prescription medications. Greater absorption was observed for the clobetasol propionate gel formulation as compared to the cream formulation in Studies performed with clobetasol propionate gel, 0.05% indicate that it is in the super-high range of potency as compared with other topical corticosteroids.Clobetasol Propionate Gel, 0.05% is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond 2 consecutive weeks is not recommended, and the total dosage should not exceed 50 g/week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis. Use your next dose at the regular time. Abnormalities seen included cleft palate, cranioschisis, and other skeletal abnormalities.There are no adequate and well-controlled studies of the teratogenic potential of clobetasol propionate in pregnant women. Greater absorption was observed for the clobetasol propionate gel formulation as compared to the cream formulation in in vitro human skin penetration studies.
Patients receiving super-potent corticosteroids should not be treated for more than 2 weeks at a time, and only small areas should be treated at any one time due to the increased risk of HPA axis suppression.If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent corticosteroid. Clobetasol propionate gel, 0.05% is a super-high potency corticosteroid formulation indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
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