Search for other works by this author on: Search for other works by this author on: I ... One school of thought is that eventually the CML will come back (unless the vaccine proves effective), although when is very debatable and it may not be for years, if ever. Search for other works by this author on:
Search for other works by this author on: The Ph chromosome carries a gene called BCR-ABL, which produces a protein called BCR-ABL.The BCR-ABL protein triggers bone marrow to keep making abnormal versions of white blood cells, which are the leukemia cells. Simona Soverini, Luana Bavaro, Caterina De Benedittis, Margherita Martelli, Alessandra Iurlo, Nicola Orofino, Simona Sica, Federica Sorà, Francesca Lunghi, Fabio Ciceri, Sara Galimberti, Claudia Baratè, Massimiliano Bonifacio, Luigi Scaffidi, Fausto Castagnetti, Gabriele Gugliotta, Francesco Albano, Antonella Vita Russo Rossi, Fabio Stagno, Francesco di Raimondo, Mariella D’Adda, Eros di Bona, Elisabetta Abruzzese, Gianni Binotto, Rosaria Sancetta, Marzia Salvucci, Isabella Capodanno, Mariella Girasoli, Sabrina Coluzzi, Immacolata Attolico, Caterina Musolino, Elisabetta Calistri, Mario Annunziata, Monica Bocchia, Stefania Stella, Anna Serra, Santa Errichiello, Giuseppe Saglio, Fabrizio Pane, Paolo Vigneri, Flavio Mignone, Maria Antonella Laginestra, Stefano Aldo Pileri, Antonio Percesepe, Elena Tenti, Gianantonio Rosti, Michele Baccarani, Michele Cavo, Giovanni Martinelli; Prospective assessment of NGS-detectable mutations in CML patients with nonoptimal response: the NEXT-in-CML study.
The resulting uncontrolled growth of these leukemia cells can cause a large increase in their concentration in the blood.
We conducted a prospective clinical trial of imatinib withdrawal in 40 chronic-phase CML patients who had sustained undetectable minimal residual disease (UMRD) by conventional quantitative polymerase chain reaction (PCR) on imatinib for at least 2 years.
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»Checkpoints on a Ph+ CML patient’s journey indicate response to treatment.
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Still undetectable; Still undetectable.
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Search for other works by this author on: Fifty-one patients (22 failure, 29 warning) who were negative for mutations by SS had low-level mutations detectable by NGS.
Search for other works by this author on: More than half of CP CML patients achieved MMR (57.1%) and 40% of AP/BP CML / Ph+ ALL achieved undetectable disease. Search for other works by this author on:
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Chronic myeloid leukemia, or CML, is a cancer that occurs when the blood-forming cells of the bone marrow (the soft, spongy tissue in the center of bones) make too many white blood cells, including immature ones.Most patients with CML – approximately 95% – have a genetic abnormality that produces an abnormal chromosome in bone marrow stem cells, known as the Philadelphia chromosome (abbreviated “Ph chromosome” or simply “Ph”).
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Over time, these abnormal cells crowd out healthy red blood cells and platelets as well as normal white cells, which can have negative effects on your health.Targeted Ph+ CML therapies have been developed to slow the reproduction of leukemia cells. »
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CML treatment can be thought of as a series of steps or milestones. Search for other works by this author on:
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These therapies work to reduce the levels of cancer-causing proteins and Ph+ CML cells. A series of 236 consecutive CML patients with failure (n = 124) or warning (n = 112) response to TKI therapy were analyzed in parallel by SS and NGS in 1 of 4 reference laboratories. Don't already have an account? Search for other works by this author on: Tue, 29/12/2009 - 11:41pm . Search for other works by this author on: Search for other works by this author on:
CML is a clonal, multilineage myeloproliferative disorder defined by the presence of a BCR-ABL fusion gene originating in a hematopoietic stem cell.
Some patients who respond exceptionally well to treatment may achieve a level of leukemic cells that is nearly undetectable. Search for other works by this author on: Although Sanger sequencing (SS) is considered the gold standard for
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