Physicians should closely follow the growth of children and adolescents taking corticosteroids by any route.Inform patients that long-term use of ICS may increase the risk of some eye problems (cataracts or glaucoma); consider regular eye examinations.Inform patients of adverse effects associated with betaTrademarks are owned by or licensed to the GSK group of companies.Know the medicines you take. Specifically, no increased reporting of neutrophilia or changes in glucose or potassium was noted.In addition to adverse reactions reported from clinical trials, the following adverse reactions have been identified during postapproval use of any formulation of ADVAIR, fluticasone propionate, and/or salmeterol regardless of indication.
Therapy with adrenergic bronchodilators should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, and/or underlying cardiovascular disorders such as coronary insufficiency, cardiac arrhythmias, or hypertension. Some of these patients have clinical features of vasculitis consistent with Churg-Strauss syndrome, a condition that is often treated with systemic corticosteroid therapy. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine. exposure.
A causal relationship between fluticasone propionate and these underlying conditions has not been established.Advair Diskus, like all medicines containing sympathomimetic amines, should be used with caution in patients with convulsive disorders or thyrotoxicosis and in those who are unusually responsive to sympathomimetic amines. In these 2 trials, exacerbations were defined as worsening of 2 or more major symptoms (dyspnea, sputum volume, and sputum purulence) or worsening of any 1 major symptom together with any 1 of the following minor symptoms: sore throat, colds (nasal discharge and/or nasal congestion), fever without other cause, and increased cough or wheeze for at least 2 consecutive days. a significantly increased number of subjects treated with ADVAIR DISKUS 500/50 Treatment of overdosage consists of discontinuation of Advair Diskus together with institution of appropriate symptomatic and/or supportive therapy. The use of ADVAIR DISKUS is contraindicated in the following conditions: Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required [see WARNINGS AND PRECAUTIONS] acutely deteriorating asthma. These events have been chosen for inclusion due to either their Research Triangle Park, NC: GlaxoSmithKline;2010 June. Advair Diskus. Twenty-six percent (26%) of subjects using Advair Diskus 250/50 averaged 6 or more inhalations of albuterol per day over the course of the 24-week trial. and fluticasone propionate 500 mcg (16% and 14%, respectively) compared with However, fluticasone propionate and salmeterol concentrations in plasma after inhaled therapeutic doses are low and therefore concentrations in human breast milk are likely to be correspondingly low Use of Advair Diskus 100/50 in patients aged 4 to 11 years is supported by extrapolation of efficacy data from older subjects and by safety and efficacy data from a trial of Advair Diskus 100/50 in children with asthma aged 4 to 11 years ICS, including fluticasone propionate, a component of Advair Diskus, may cause a reduction in growth velocity in children and adolescents A 52-week placebo-controlled trial to assess the potential growth effects of fluticasone propionate inhalation powder (FLOVENT ROTADISK) at 50 and 100 mcg twice daily was conducted in the U.S. in 325 prepubescent children (244 males and 81 females) aged 4 to 11 years. In the subjects treated with salmeterol, the incidence of pneumonia was the same (3%) in both age groups. Keep out of reach of children.Advair Diskus should be stored inside the unopened moisture-protective foil pouch and only removed from the pouch immediately before initial use. is based upon 1 U.S. trial of 12 weeks' treatment duration. Very rare anaphylactic reaction in Advair HFA is indicated for the twice-daily treatment of asthma in patients aged 12 years and older. beta- 2 adrenergic bronchodilators - cardiovascular.
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