Based on the wide experience with this drug and its chemical structure and pharmacological properties, it would not be expected to present a risk of fetal abnormalities when used as indicated.It is not known whether this drug is excreted in human milk.
Find out what health conditions may be a health risk when taken with Oxytocin Injection A physician qualified to manage any complications should be immediately available.When properly administered, Oxytocin should stimulate uterine contractions similar to those seen in normal labor. It is indicated for (1) induction of labor in patients with a medical indication for the initiation of labor, such as Rh problems, maternal diabetes, pre-eclampsia at or near term, when delivery is in the best interest of mother and fetus or when membranes are prematurely ruptured and delivery is indicated; (2) stimulation or reinforcement of labor, as in selected cases of uterine inertia; (3) adjunctive therapy in the management of incomplete or inevitable abortion. Acetic acid may have been added for pH adjustment (pH 3.0-5.0). Oxytocin doses in the BNF may differ from those in the product literature. Find out what health conditions may be a health risk when taken with Oxytocin Synthetic Injection The structural formula is:Oxytocin injection (synthetic) acts on the smooth muscle of the uterus to stimulate contractions; response depends on the uterine threshold of excitability. Oxytocin stimulates rhythmic contractions of the uterus, increases the frequency of existing contractions and raises the tone of the uterine musculature. It exerts a selective action on the smooth musculature of the uterus, particularly toward the end of pregnancy, during labor and immediately following delivery. Prolonged intravenous administration at high doses with large volume of fluid (which is possible in inevitable or missed miscarriage or postpartum haemorrhage) may cause water intoxication with hyponatraemia.
Each mL of Oxytocin Injection, USP (synthetic), intended for intravenous infusion or intramuscular injection, possesses an oxytocic activity equivalent to 10 USP Oxytocin Units and contains chlorobutanol anhydrous (chloral derivative) 0.5%.
Hyperstimulation with strong (hypertonic) or prolonged (tetanic) contractions, or a resting tone of 15 to 20 mm H Dosage of Oxytocin is determined by uterine response. Synthetic Oxytocin does not possess the cardiovascular effects, such as elevation of blood pressure, as exhibited by vasopressin found in posterior pituitary injection.Oxytocin injection (synthetic) is indicated for the initiation or improvement of uterine contractions, where this is desirable and considered suitable, in order to achieve early vaginal delivery for fetal or maternal reasons. Maternal death due to Oxytocin-induced water intoxication has been reported.The following adverse reactions have been reported in the fetus or infant:Overdosage with Oxytocin injection (synthetic) depends essentially on uterine hyperactivity whether or not due to hypersensitivity to this agent.
The dose may be gradually increased in increments of no more than 1 to 2 mU/min., until a contraction pattern has been established which is similar to normal labor.The fetal heart rate, resting uterine tone, and the frequency, duration, and force of contractions should be monitored.The Oxytocin infusion should be discontinued immediately in the event of uterine hyperactivity or fetal distress. The following dosage information is based upon the various regimens and indications in general use.Intravenous infusion (drip method) is the only acceptable method of administration for the induction or stimulation of labor.Accurate control of the rate of infusion flow is essential. WebMD provides common contraindications for Oxytocin Synthetic Injection. If uterine contractions become too powerful, the infusion can be abruptly stopped, and oxytocic stimulation of the uterine musculature will soon wane.An intravenous infusion of a non-Oxytocin containing solution should be started. Oxytocin Injection, USP (synthetic) is supplied as follows:We comply with the HONcode standard for trustworthy health information -
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