(Multiples of the maximum recommended human dose in this section are calculated on a body surface area basis using total mg/mThere were maternotoxic effects but no teratogenic effects in mice given cabergoline at doses up to 8 mg/kg/day (approximately 55 times the maximum recommended human dose) during the period of organogenesis.A dose of 0.012 mg/kg/day (approximately 1/7 the maximum recommended human dose) during the period of organogenesis in rats caused an increase in post-implantation embryofetal losses.
Are there any other precautions or warnings for this medication? Care should be exercised when administering Dostinex with other medications known to lower blood pressure.Dostinex is not indicated for the inhibition or suppression of physiologic lactation. The optimum coating solvent ratio for spray-coating the osmotic tablets was water : alcohol (60:34) and it resulted in a coating with smooth texture and which successfully modulated drug release lag time of the coated tablets.
Doses of 4 mg/kg/day (approximately 150 times the maximum recommended human dose) during the period of organogenesis in the rabbit caused an increased occurrence of various malformations. In the placebo-controlled study (placebo n=20; cabergoline n=168), Dostinex produced a dose-related decrease in serum prolactin levels with prolactin normalized after 4 weeks of treatment in 29%, 76%, 74% and 95% of the patients receiving 0.125, 0.5, 0.75, and 1.0 mg twice weekly respectively.In the 8-week, double-blind period of the comparative trial with bromocriptine (cabergoline n=223; bromocriptine n=236 in the intent-to-treat analysis), prolactin was normalized in 77% of the patients treated with Dostinex at 0.5 mg twice weekly compared with 59% of those treated with bromocriptine at 2.5 mg twice daily. Nonrenal and renal clearances for cabergoline are about 3.2 L/min and 0.08 L/min, respectively. Cabergoline does not cause enzyme induction and/or inhibition in the rat.
Whole body autoradiography studies in pregnant rats showed no fetal uptake but high levels in the uterine wall. Prolactin inhibitors such as cabergoline are used to treat different types of medical problems that occur when too much prolactin, a hormone produced by the pituitary gland in the brain.
Conclusion: The optimum ratio of water/alcohol (60:34) as coating solvent produced a smooth coated
Dostinex should not be used in patients with a history of, or current signs and or clinical symptoms of, respiratory or cardiac disorders linked to fibrotic tissue.Following diagnosis of pleural effusion or pulmonary fibrosis, the discontinuance of cabergoline has been reported to result in improvement of signs and symptoms.Erythrocyte sedimentation rate (ESR) has been found to be abnormally increased in association with pleural effusion/fibrosis.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. What other drugs could interact with this medication? Dostinex: Cabergoline belongs to a class of medications known as prolactin inhibitors. Restoration of menses occurred in 77% of the women treated with Dostinex, compared with 70% of those treated with bromocriptine. Heart failure, pleural effusion, pulmonary fibrosis, and gastric or duodenal ulcer occurred rarely. The Dostinex brand name has been discontinued in the U.S.
What form(s) does this medication come in? Use of bromocriptine, another dopamine agonist for this purpose, has been associated with cases of hypertension, stroke, and seizures.Since cabergoline is extensively metabolized by the liver, caution should be used, and careful monitoring exercised, when administering Dostinex to patients with hepatic impairment.As with other ergot derivatives, pleural effusion or pulmonary fibrosis have been reported following long-term administration of cabergoline. 7.
Cabergoline belongs to a class of medications known as Cabergoline stops the brain from making and releasing prolactin from the pituitary gland.
Its empirical formula is CCabergoline is a white powder soluble in ethyl alcohol, chloroform, and N, N-dimethylformamide (DMF); slightly soluble in 0.1N hydrochloric acid; very slightly soluble in n-hexane; and insoluble in water.Dostinex Tablets, for oral administration, contain 0.5 mg of cabergoline.
It is important to use this medication exactly as prescribed by your doctor.
Radioactivity in the pituitary exceeded that in plasma by >100-fold and was eliminated with a half-life of approximately 60 hours. High prolactin levels may cause bone loss, irregular menstrual cycles, infertility, unwanted breast milk production, or sexual problems.This medicine also treats high levels of prolactin caused by certain tumors.
The prolonged prolactin-lowering effect of cabergoline may be related to its slow elimination and long half-life.In animals, based on total radioactivity, cabergoline (and/or its metabolites) has shown extensive tissue distribution.
The drug/solvent ratio is the ratio of the quantity of drug used to the total quantity of solvent consumed. Serum creatinine measurements can also be used to help in the diagnosis of fibrotic disorder.Pathological gambling, increased libido, and hypersexuality have been reported in patients treated with dopamine agonists including cabergoline. coated layer. Select one or more newsletters to continue.
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