duloxetine contraindications micronase


The statistically significantly superior effect of 60 mg versus placebo was present as early as Week 1 and persisted throughout each study. Signs and symptoms of hyponatremia include headache, difficulty concentrating, memory impairment, confusion, weakness, and unsteadiness, which may lead to falls.
The maximum fluoxetine dose should not exceed 80 mg/day.In the controlled clinical trials of fluoxetine supporting its effectiveness in the treatment of OCD, patients were administered fixed daily doses of 20, 40, or 60 mg of fluoxetine or placebo [seeIn adolescents and higher weight children, initiate treatment with a dose of 10 mg/day. Therefore, height and weight should be monitored periodically in pediatric patients receiving fluoxetine [seePROZAC is approved for use in pediatric patients with MDD and OCD [see Significant toxicity on muscle tissue, neurobehavior, reproductive organs, and bone development has been observed following exposure of juvenile rats to fluoxetine from weaning through maturity. After 1 week at 10 mg/day, increase the dose to 20 mg/day. PROZAC can also prolong the QT interval.Although the exact mechanism of PROZAC is unknown, it is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin.Studies at clinically relevant doses in man have demonstrated that fluoxetine blocks the uptake of serotonin into human platelets. Patients receiving warfarin therapy should be carefully monitored when fluoxetine is initiated or discontinued [see There are no clinical studies establishing the benefit of the combined use of ECT and fluoxetine. Revised: Apr 2020The following adverse reactions are discussed in more detail in other sections of the labeling:When using PROZAC and olanzapine in combination, also refer to the Adverse Reactions section of the package insert for Symbyax.Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect or predict the rates observed in practice.Multiple doses of PROZAC have been administered to 10,782 patients with various diagnoses in US clinical trials. Due to the risk of serious ventricular arrhythmias and sudden death potentially associated with elevated plasma levels of thioridazine, thioridazine should not be administered with fluoxetine or within a minimum of 5 weeks after fluoxetine has been discontinued [see In 2 studies, previously stable plasma levels of imipramine and desipramine have increased greater than 2- to 10-fold when fluoxetine has been administered in combination.

Of the 1578 cases of overdose involving fluoxetine hydrochloride, alone or with other drugs, reported from this population, there were 195 deaths.Among 633 adult patients who overdosed on fluoxetine hydrochloride alone, 34 resulted in a fatal outcome, 378 completely recovered, and 15 patients experienced Among pediatric patients (ages 3 months to 17 years), there were 156 cases of overdose involving fluoxetine alone or in combination with other drugs. Rat exposures to the major metabolite, norfluoxetine, are approximately 0.3-0.8, 1-8, and 3-20 times, respectively, the pediatric exposure at the MRHD.A specific effect on bone development was reported in juvenile mice administered fluoxetine by the Use Of PROZAC In Combination With Olanzapine In Children And Adolescents Safety and efficacy of PROZAC and olanzapine in combination in patients 10 to 17 years of age have been established for the acute treatment of depressive episodes associated with Bipolar I Disorder.
In Study 1, patients receiving PROZAC experienced mean reductions of approximately 4 to 6 units on the YBOCS total score, compared with a 1-unit reduction for placebo patients. In addition, fluoxetine treatment was associated with a decrease in alkaline phosphatase levels.

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