Learn about drug interactions between fluconazole oral and colchicine and use the RxList drug interaction checker to check drug combinations. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.Serious. Learn about drug interactions between colchicine oral and fluconazole oral and use the RxList drug interaction checker to check drug combinations. The study is based on colchicine and fluconazole (the active ingredients of Colchicine and Diflucan, respectively), and Colchicine and Diflucan (the brand names). Does Fluconazole Interact with other Medications? Please check with a physician if you have health questions or concerns. Similarly,coadministration with ketoconazole increases colchicine C(max) and AUC by 102%and 212%, respectively. May be used to treat vaginal … Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. Clinical Drug Interactions Source: Medscape from WebMDDisclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. colchicine oral will increase the level or effect of fluconazole oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed This tool may not cover all possible drug interactions. Other drugs that have the same active ingredients (e.g. The information provided here is for informational purposes only. These medications are not usually taken together. Upsides. Severe Interactions. doctor or pharmacist) for more information.Your medicine may slow down how quickly your intestine and liver process colchicine.The amount of colchicine in your blood may increase and cause toxic side effects. colchicine oral will increase the level or effect of fluconazole oral by altering drug metabolism. This is the first reported case of neuromyopathy induced by administration of fluconazole to a patient undergoing long-term colchicine therapy. Fluconazole is a triazole antifungal agent that inhibits CYP2C19 (strong inhibition), CYP2C9 (moderate inhibition), and CYP3A4 (moderate inhibition) . Do not start, stop, or change the dosage of any medicine before checking with them first.Selected from data included with permission and copyrighted by First Databank, Inc. Deaths have been reported.Let your healthcare professionals (e.g. generic drugs) are not considered. This information is generalized and not intended as specific medical advice. Contact your healthcare professional (e.g. Make sure your doctor knows if you have any kidney or liver problems, which may make the interaction worse. Colchicine (Colcrys) is also used to treat familial Mediterranean fever (FMF; an inborn condition that causes episodes of fever, pain, and swelling of the stomach area, lungs, and joints) in adults and children 4 years of age and old… Colchicine/Moderate CYP3A4 Inhibitors Interactions. This information is generalized and not intended as specific medical advice. -Oral fluconazole recommended as preferred therapy; IV dosing recommended as alternative therapy for infants and children of all ages. Let your doctor know right away if you have any unexplained muscle weakness or pain, numbness or tingling in the fingers or toes; unusual bleeding or bruising; abdominal pain; nausea; severe diarrhea or vomiting; feeling weak or tired; increased infections; or pale or gray color of the lips, tongue, or palms of hands.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Your doctor may need to change your medicine or the dose of your colchicine. Drugs A-Z Pill Identifier Supplements Symptom Checker Diseases Dictionary Media -If neonate creatinine level is greater than 1.2 mg/dL for 3 consecutive doses, the dosing interval for the higher dose may be extended to 12 mg/kg every 48 hours until serum creatinine level is less than 1.2 mg/dL. These medicines may interact and cause very harmful effects. May be used to treat certain fungal or yeast infections. doctor or pharmacist) know that you are taking these medicines together or if you have taken your other medicine in the previous 14 days. Avoid use of colchicine with strong CYP3A4 inhibitors. Copyright © 2018 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Other antibiotics that are strong CYP3A4 inhibitorsinclude itraconazole and telithromycin, whereas erythromycin and fluconazole are … Consult your healthcare …
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