fluticasone cream for lips differin


I have two discoloured/whitish spots (about 4 mm diameter each) on my lower lip.
see Use In Specific Populations (8.4) and Clinical Pharmacology (12.2)Table 1: Adverse Reactions from Controlled Clinical Trials (N=438)Table 2: Adverse Events Occurring in ≥1% of Patients from Either Arm from Controlled Clinical Trials (n=438)see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2)see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2)Hypothalamic-Pituitary-Adrenal (HPA) Axis SuppressionTable 3: Complete Clearance Rate For Patients with Clinically Significant Signs at BaselineImportant: Fluticasone Propionate Lotion, 0.05% is for use on skin only (topical).Before using Fluticasone Propionate Lotion, 0.05%, tell your healthcare provider about all of your medical conditions, including if you:Tell your healthcare provider about all the medicines you take,How should I use Fluticasone Propionate Lotion, 0.05%?What are possible side effects with Fluticasone Propionate Lotion, 0.05%?Fluticasone Propionate Lotion, 0.05% may cause serious side effects, including:Fluticasone Propionate Lotion, 0.05% can pass through your skin and maySkin problems, including skin reactions or thinning of your skin (atrophy), skin infections, and allergic reactionsThe most common side effects of Fluticasone Propionate Lotion, 0.05%How should I store Fluticasone Propionate Lotion, 0.05%?Keep Fluticasone Propionate Lotion, 0.05% and all medicines out of the reach of children.General information about the safe and effective use of Fluticasone Propionate Lotion, 0.05%.What are the ingredients in Fluticasone Propionate Lotion, 0.05%?We comply with the HONcode standard for trustworthy health information - Fluticasone Propionate Lotion, 0.05% contains fluticasone propionate [S-Fluoromethyl 6α, 9α-difluoro-11β-hydroxy-16α-methyl-3-oxo-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate], a synthetic fluorinated corticosteroid, for topical use.

Evaluation of HPA axis suppression may be done by using the cosyntropin stimulation test.The effects of fluticasone propionate lotion, 0.05% on HPA axis function in pediatric patients were investigated in two trials. No treatment related effects on embryofetal toxicity or teratogenicity were noted at 15 μg/kg/day (less than the MRHD in adults based on body surface area comparisons).Subcutaneous doses of 10, 30 and 100 μg/kg/day of fluticasone propionate were administered to pregnant female rats in two embryofetal development studies (one study administered fluticasone propionate from gestation days 6 to 15 and the other study from gestation days 7 to 17). Differin (adapalene) is a topical medicine (a medication that is applied to the surface of the skin) similar to vitamin A. These were local cutaneous reactions, usually mild and self-limiting, and consisted primarily of burning/stinging (2%).
Differin can make your skin more sensitive to sunlight and sunburn may result.

[In another open label HPA axis suppression trial in which fluticasone propionate lotion, 0.05% was also applied twice daily (rather than the indicated dosing regimen of once daily), 56 pediatric subjects (ages ≥3 months to 12 months), were enrolled [The adverse reactions included 2 cases of Herpes simplex at the application site (3.6%) and 3 cases of bacterial skin infections (5.4%).The following local adverse reactions have been identified during post-approval use of fluticasone propionate lotion, 0.05%: erythema, edema/swelling, and bleeding.The following systemic adverse reactions have been identified during post-approval use of fluticasone propionate cream and fluticasone propionate ointment: immunosuppression/The following local adverse reactions have also been reported with the use of topical corticosteroids, and they may occur more frequently with the use of occlusive dressings or higher potency corticosteroids. In the presence of maternal toxicity, fetal effects noted at 100 μg/kg/day (less than the MRHD in adults based on body surface area comparisons) included decreased fetal weights, omphalocele, cleft palate, and retarded skeletal ossification. Differin can make you sunburn more easily.

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