Acyclovir 5% ointment should not be used for the prevention of recurrent HSV infections; data indicating that the ointment prevents recurrent HSV infection is not available.The recommended dose, frequency of application, and length of treatment with topical acyclovir should not be exceeded. No significant effect on healing or crusting of lesions was noted in females.
Mechanism of Antiviral Action: Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV).The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV.
Because FSA funds are available to you on the first day of your plan year, you must be able to receive full reimbursement for your contribution.
Keep out of your mouth, nose, and eyes (may burn). Many common allergens are also likely to cause asthma and these include milk, eggs, peanuts, soy, wheat, shellfish and fish. However, systemic therapy (e.g., oral or IV acyclovir) generally is preferred for the treatment of mucocutaneous herpes simplex infections in immunocompromised individuals.An ophthalmic ointment containing acyclovir 3% (not currently available) has been used in the topical treatment of HSV ophthalmic infections; however, Acyclovir 5% cream is applied topically to affected areas of the lips and surrounding skin. The manufacturer states that acyclovir ointment may be used topically for the management of initial genital herpes; however, topical therapy is not usually recommended for the treatment of genital herpes.Acyclovir 5% cream is used topically for the treatment of recurrent herpes labialis (perioral herpes, cold sores, fever blisters) in immunocompetent adults and children 12 years of age or older. There are no adequate and controlled studies to date using acyclovir in pregnant women, and the drug should be used during pregnancy only when the potential benefits justify the possible risks to the fetus.Although it is not known whether acyclovir is distributed into milk following topical application, the drug is distributed into milk following oral or IV administration. Efficacy of acyclovir 5% cream in immunocompromised individuals has not been established. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. By using the FSA debit card, your expenses are auto-adjudicated (electronically approved or disapproved) from the card and you may not need to submit additional receipts to your FSA Administrator.
Avoid getting this medication in your eyes.If this happens, wash right away with plenty of water. Following oral administration of acyclovir in 2 nursing women, milk acyclovir concentrations were 0.6-4.1 times the simultaneous maternal plasma drug concentrations. In several placebo-controlled studies, the frequency and type of these adverse effects were similar for acyclovir- and placebo-treated patients; therefore, these effects probably resulted from contact with or manipulation of the characteristically tender genital lesions.In clinical studies evaluating acyclovir 5% cream, dry or cracked lips, desquamation, dry or flaking skin, burning or stinging skin, and pruritus were the most frequently reported adverse effects.The manufacturer states that adverse systemic effects following overdosage with topically applied acyclovir 5% cream or ointment are unlikely since the drug undergoes minimal percutaneous absorption.The development of viral mutants with decreased in vitro susceptibility to acyclovir has occurred following in vitro exposure of HSV isolates to the drug and also has been observed in a small number of immunocompromised patients after repeated systemic therapy with the drug; however, the clinical importance of this decreased in vitro susceptibility is not known since the presence of these viruses did not appear to be associated with a worsening of clinical illness and, in some instances, the virus disappeared spontaneously. Says McCormack, “Substituting fish for red meat whenever possible is always a good thing.”Sulfites, commonly used as a preservative in alcoholic beverages, may sometimes worsen asthma symptoms, particularly aggravating wheezing and difficulty breathing, say experts at the British Allergy Foundation’s It’s long been thought that dairy products like milk and ice cream worsen asthma symptoms because they increase the production of mucus in the lungs.
Therefore, acyclovir ointment and cream should be used with caution in nursing women.
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