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Serotonin syndrome is caused by a variety of pharmacological mechanisms. He has been on advisory boards for Astra-Zeneca, Bristol-Myers Squibb, Eli Lilly and Servier in the past 2 years but has no consultancies with or pecuniary interests in any pharmaceutical company. Its combination with SSRIs can produce pharmacological effects similar to TCAs but with a more favourable side-effect profile due to a lower affinity for other receptors. A prospective 4-week semi-naturalistic study ( Employing the same rationale as SSRI–reboxetine combination, reboxetine has been added for patients not responding to venlafaxine alone in an open-label series – reasonable response rates have been reported ( Combinations of SSRI–MAOI and TCA–MAOI have been considered in the previous sections. A literature review of antidepressant combination therapyLithium and tricyclic augmentation of fluoxetine treatment for resistant major depression: a double-blind, controlled studyDouble-blind study of high-dose fluoxetine versus lithium or desipramine augmentation of fluoxetine in partial responders and nonresponders to fluoxetineTricyclic antidepressant pharmacology and therapeutic drug interactions updatedCombined treatment with venlafaxine and tricyclic antidepressants in depressed patients who had partial response to clomipramine and imipramineSelective serotonin reuptake inhibitors combined with venlafaxine in depressed patients who had partial response to venlafaxine: four casesProgress in Neuro-Psychopharmacology and Biological PsychiatryVenlafaxine–mirtazapine combination in the treatment of persistent depressive illnessElectroconvulsive therapy in depressive illness that has not responded to drug treatmentLow-dose trazodone as a hypnotic in patients treated with MAOIs and other psychotropics: a pilot studyCombination therapy using moclobemide with tricyclic and tetracyclic antidepressants to treat therapy-resistant depressionSelective serotonin reuptake inhibitor-induced serotonin syndrome: reviewCombined treatment with imipramine and mianserin. All Rights Reserved Optimising antidepressant use by attempting to ensure that patients take an adequate dose for an adequate length of time with measures to improve concordance is the first strategy recommended for managing incomplete response. In the STAR*D sample, 22.4% had a mild, 24.5% moderate and 6.1% severe to intolerable side-effect burden ( This combination has been tried with a similar rationale to the SSRI–trazodone combination. Nausea, headaches, nervousness with insomnia, urinary retention and periorbital oedema were reported, especially in combination with fluoxetine. Low doses of venlafaxine combined with fluoxetine can cause urinary retention, constipation, dry mouth and blurred vision. Hypomanic switches were reported in the RCT group of in-patients with treatment-resistant major depression ( There are two double-blind controlled studies of TCAs used in combination with mianserin ( As far as we are aware, there are no studies that investigate the combination of TCAs with mirtazapine, although the principles behind the combination would be similar to those for mianserin.

Mannchen, Julie K. This might be due to adrenergic stimulation mimicking anticholinergic effects. Haddad, Peter M. There is very little evidence, however, to guide practice in treatment-refractory patients. No studies were found for the MAOI–SNRI combination. They might want you to start following the low tyramine diet before you start, too. Jamshidi, Fariba Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time) Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node) Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent) Spinal fusion surgery

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