2019 Feb 6;24(3):583. doi: 10.3390/molecules24030583.Medicine (Baltimore). Nitroglycerin, also known as glyceryl trinitrate (GTN), is a medication used for heart failure, high blood pressure, anal fissures, painful periods, and to treat and prevent chest pain caused by decreased blood flow to the heart (angina) or due to the recreational use of cocaine.
Glyceryl trinitrate, isosorbide dinitrate, and isosorbide-5-mononitrate are organic nitrate esters commonly used in the treatment of angina pectoris, myocardial infarction, and congestive heart failure. 2004 Aug;142(7):1105-14. doi: 10.1038/sj.bjp.0705791. Are there signi-ficant differences among these three nitrates?
... vardenafil, medicines for angina or heart pain such as glyceryl trinitrate (GTN), isosorbide dinitrate, amyl or butyl nitrite, medicines for high blood pressure or depression (tricyclic anti-depressants), acetyl cysteine or alteplase ; … Nitroglycerin is the fastest-working medicine to relieve chest pain, but make sure to sit down before taking it. 1994 Oct;8(5):693-9. doi: 10.1007/BF00877116.Akentieva NP, Sanina NA, Gizatullin AR, Shkondina NI, Prikhodchenko TR, Shram SI, Zhelev N, Aldoshin SM.Front Pharmacol. 1990 Feb;26(2):175-84. doi: 10.1016/0167-5273(90)90031-y.Pulm Pharmacol Ther.
This site needs JavaScript to work properly. However, the relationship between relaxant responses to sodium nitroprusside and airway size was not as marked as for glyceryl trinitrate.
ScienceDirect ® is a registered trademark of Elsevier B.V.Isosorbide dinitrate and glyceryl trinitrate: Demonstration of cross tolerance in the capacitance vesselsScienceDirect ® is a registered trademark of Elsevier B.V. Although less potent than isoproterenol, sodium nitroprusside (10(-6) to 10(-4) M) was effective in relaxing all the airway preparations. 1994 Oct;8(5):693-9. doi: 10.1007/BF00877116.Negrescu EV, Sazonova LN, Baldenkov GN, Mukharliamov NM, Mazaev AV, Tkachuk VA.Int J Cardiol.
Venous capacitance was assessed using the radionuclide blood pool method, with relative changes in regional blood volume measured in the forearm in 6 patients and the splanchnic circulation in 4 patients.
14. Short-acting nitrates such as sublingual nitroglycerin, isosorbide dinitrate, or nitroglycerin spray for treatment of acute attacks.
Ultimately, through various processes, the protein kinase lowers intracellular calcium; an increased uptake to and a decreased release from intracellular stores seem to be particularly important.
In this investigation, the effects of ISDN and GTN on NOS activity in the presence or absence of oxyhemoglobin under hypoxia and normoxia were studied. Similar to glyceryl trinitrate, sodium nitroprusside was less effective in small than in large airways.
Isosorbide mononitrate has one nirate group and isosorbide dinatrate has 2 nitro groups. Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well. Isosorbide dinitrate is good for chest pain, but you have to be able to stick to your dosing schedule or it won't work as well.
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By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. 2013 Feb;26(1):112-20. doi: 10.1016/j.pupt.2012.05.007. Menu. 1987 Sep;34(3):391-403. doi: 10.2165/00003495-198734030-00005.Cardiovasc Drugs Ther.
1992 Jun;5(2):97-102. doi: 10.1016/0952-0600(92)90025-c.Cardiovasc Drugs Ther. 2008 Oct;133(44):2277-82. doi: 10.1055/s-0028-1091272.
1985 Jul;37(7):502-4. doi: 10.1111/j.2042-7158.1985.tb03052.x.Br J Pharmacol. Glyceryl Trinitrate is used for Angina Pectoris, Hypertension During Surgeries, Chronic Anal Fissures etc. Menu.
However, reports about the clinical efficacy of the nitrates in the treatment of asthma are conflicting.
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