• An up to 2-fold increased risk of having breast cancer diagnosed is reported in women taking combined oestrogen-progestogen therapy for more than 5 years. T3 resin uptake is decreased, reflecting the elevated TBG.
It does not matter if you take this medicine before or after food. Within 72 hours excretion is complete. If you notice any changes to your breasts, see your doctor. The grey tablets each contain 1mg of estradiol (as hemihydrate) and 10 mg of dydrogesterone. It does not contain all the available information. These medicines may be affected by Femoston, or may affect how well it works. vaginal itching, inflammation or fluid discharge If you have trouble remembering when to take your medicine, ask your pharmacist for advice. The risk of developing blood clots in your blood vessels may be temporarily increased after surgery, serious injury or having to stay in bed for a long period of time. After the age of 40, and especially after the menopause, some women develop osteoporosis. Immediately telephone your doctor, or the Poisons Information Centre 13 11 26 or go to Accident and Emergency at your nearest hospital, if you think you or anyone else may have taken too much Femoston.
Data is presented as mean (SD).Oestrogens can be found either unbound or bound. Include foods that are good sources of calcium and Vitamin D in your daily diet and exercise regularly. The above list includes very serious side effects. If you are having regular periods, you may start taking Femoston on the first day of your period. The Women's Health Initiative Memory Study indicated increased risk of dementia in women aged 65-79 years taking conjugated estrogens and MPA. any of the ingredients listed at the end of this leaflet Tell your doctor if you have or have had any of the following medical conditions: Menopause may be natural or occur after surgery or medical treatment. The percentage of women who maintained or gained BMD in the 3 hip areas during treatment was 71, 66 and 81% respectively.Absorption of estradiol is dependent on the particle size: micronized estradiol is readily absorbed from the gastrointestinal tract.The following table provides the mean steady state pharmacokinetic parameters of estradiol (E2), estrone (E1) and estrone sulphate (E1S) for each dose of micronized estradiol. • Known or suspected oestrogen-dependent malignant tumours (e.g. If you have forgotten to take more than one tablet, discuss this with your doctor. After discontinuation of HRT, bone mass is lost at a rate similar to that in untreated women.Evidence from the WHI trial and meta-analysed trials shows that current use of HRT, alone or in combination with a progestogen – given to predominantly healthy women – reduces the risk of hip, vertebral, and other osteoporotic fractures. If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. painful swelling in the calves or thighs • Absolute risk estimations based on results of the largest randomised placebo-controlled trial (WHI-study) and the largest meta-analysis of prospective epidemiological studies are presented.Incidence per 1000 never-users of HRT over a 5 year period*Taken from baseline incidence rates England in 2015 in women with BMI 27 (kg/m2)Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately. Dydrogesterone is a hormone called a progestogen. Tell your doctor or pharmacist if you have any allergies to any other medicines, foods, preservatives or dyes. The risk of osteoporosis is increased by lack of estrogen. When you come to the end of these tablets, start taking the tablets in the other half of the pack marked "2".
After stopping treatment risk may remain elevated for at least 10 years. • Herbal preparations containing St John's Wort (Hypericum perforatum) may induce the metabolism of oestrogens and progestogens. Audio under revision, check back soon It should be taken into account that these conditions may recur or be aggravated during treatment with Femoston-conti 1mg/ 5mg film-coated tablets, in particular: The occurrence of such an event is more likely in the first year of HRT than later (see section 4.8). Your doctor or nurse can show you how to check your breasts properly. By continuing to browse the site you are agreeing to our policy on the use of cookies. Other side effects not listed above may occur in some people. The major unconjugated and conjugated metabolites are estrone and estrone sulphate. If it has expired or is damaged return it to your pharmacist for disposal.
• Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism) Irregular bleeding and/or spotting appeared in 15 % of the women during the first 3 months of treatment and in 12% during months 10 - 12 of treatment.Oestrogen deficiency at menopause is associated with increase in bone turnover and decline in bone mass.
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