How abuse might play into CP/CPPS is unclear.Evidence of the trend to look at the socioeconomic effects of CP/CPPS was a study that showed female partners of patients suffered more depression and had poorer physical and mental health overall than other women.The cause or causes of CP/CPPS are still speculative, but there’s more evidence for dysfunction in the “fight or flight” neural-hormonal systems of the body. In the urine and expressed prostatic fluid of men with CP/CPPS, these researchers measured levels of markers thought to indicate allostatic overload. Before taking milk thistle, talk to your healthcare provider if you take any medications that are changed by the liver.Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.Some medications are changed and broken down by the liver. The effects lasted from 6 to 18 months in the responders. Among the 66 patients, 33 elected to undergo a repeat biopsy because their PSAs were still high. The investigators believe these differences suggest that autonomic changes may play a role in CP/CPPS and might give insight into how to use autonomic drugs and sympathetic alpha blockers for men with CP/CPPS.Jin-Kwan Jeong, Yong-Jin Kim, Ji-Kan Ryu, Kwoan-Youb Choo, Shuguang Piao, Yeonsook Moon, Do-Hwan Seong, In-Young Hyun, Wonsick Choe, Jun-Kyu Suh*, Incheon, Republic of KoreaThese Korean researchers used a new technique to detect deep-seated infections, called technetium-99(Tc-99) ciprofloxacin imaging, to look for bacterial infection in seminal vesicles in men diagnosed with CP/CPPS. The investigators concluded that chronic inflammation may be a significant risk factor for development of adenocarcinoma.Jeffrey R. Springer*, M. Scott Wingo, Thomas E. Keane, Harry S. Clarke, Charleston, SCBecause prostate inflammation may have a relationship with prostate cancer, physicians often treat men who have inflammation in their biopsy specimens and elevated PSA levels (above 4.0 ng/mL) with antibiotics in an attempt to reduce PSA to normal levels. It also seems to have antioxidant and anti-inflammatory effects.There isn't enough reliable information available to know if milk thistle is safe to apply to the skin or inject into the body.Milk thistle might decrease the effects of estrogen pills by blocking how estrogen works in the body.Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.Indinavir (Reyataz) is a drug that is changed and broken down by the liver. Overall sexual scores improved by 43% in men who rated their condition as markedly improved, but only 10% (which was not statistically significant) in the men who rated their condition as moderately improved. There were also some differences between the populations in the location, number of sites, and types of pain/discomfort. Analysis showed that being the partner of a man with CP/CPPS had a direct impact on the woman’s depression and physical health quality of life. The therapy includes release of trigger points in internal pelvic floor and external muscles through massage as well as a type of relaxation therapy termed “paradoxical” because it involves accepting tension. Those markers included corticotropin releasing hormone (CRH), neuropeptide Y (NPY), dehydroepiandrosterone (DHEA), epidermal growth factor (EGF), and galanin.
Jim C. Hu*, Michael J. Barry, Boston, MA; Carol L. Link, Watertown, MA; Mary McNaughton-Collins, Boston, MA; John B. McKinlay,, Boston, MAIn the Boston Area Community Health (BACH) study, researchers surveyed a diverse, urban sample of men about their history of sexual, physical, emotional abuse.
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