Earlier studies combining short acting drugs from these classes require multiple dosing and were associated with poor compliance. The fixed combination of perindopril and amlodipine will be indicated for hypertensive patients with uncontrolled hypertension or cardiovascular risk factors.
The advantage of fixed combinations resides in the fact that they increase compliance with treatment by reducing the number of pills taken by the patients.
2014 Nov 3;10(1):50-56. doi: 10.1515/med-2015-0011. as a group, calcium channel blockers -- including amlodipine, diltiazem, or verapamil -- rarely cause erectile dysfunction.
Free PMC article Unable to load your collection due to an error A fixed combination of the ACE inhibitor perindopril and the calcium channel blocker amlodipine proves optimal as has been shown by the results of the ASCOT-BPLA study. 2006 Sep;48(3):359-61. doi: 10.1161/01.HYP.0000238045.76905.94. Five mg amlodipine and 10 mg lisinopril monotherapy achieved the target blood pressure in 71% and 72% patients respectively. There was a significant additional blood pressure lowering effect with the combination when compared either with amlodipine or lisinopril alone. Twenty four patients with diastolic blood pressure (DBP) between 95 and 104 mm Hg received amlodipine 2.5 mg and 5 mg, lisinopril 5 mg and 10 mg, and their combination as per a prior randomisation schedule. Hypertens Res.
1 Numerous studies have demonstrated the efficacy of CCB in controlling blood pressure (BP) and preventing the adverse effects of chronic hypertension, except for heart failure. 2003 Nov;16(11 Pt 2):50S-54S.
We strongly believe that it will improve the control of hypertension in our hypertensive patients, and improve the cardioprotective and nephroprotective effect of hypertension therapy. It was decided to perform a randomised double blind, crossover study with the long acting calcium channel blocker amlodipine and the long acting ACE inhibitor lisinopril, given either alone or in combination in essential hypertension. 2008 Aug;31(8):1603-10. doi: 10.1291/hypres.31.1603.Mourad JJ, Le Jeune S, Pirollo A, Mourad C, Gaudouen Y, Lopez-Sublet M.Curr Med Res Opin. 1996 Jun;27(6):1325-8. doi: 10.1161/01.hyp.27.6.1325.Miranda RD, Mion D Jr, Rocha JC, Kohlmann O Jr, Gomes MA, Saraiva JF, Amodeo C, Filho BL.Clin Ther.
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The Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial (ALLHAT) compared in >30 000 high-risk hypertensive patients the effects on coronary heart disease of 3 treatment strategies: (1) based on the diuretic chlorthalidone, (2) the calcium-channel blocker (CCB) amlodipine, and (3) the angiotensin converting-enzyme (ACE) inhibitor lisinopril, respectively. A fixed combination of ramipril with amlodipine is an effective antihypertensive drug with a good tolerability profile. Calcium channel blockers (CCB) are a commonly prescribed class of antihypertensive medications. Introduction.
It was decided to perform a randomised double blind, crossover study with the long acting calcium channel blocker amlodipine and the long acting ACE inhibitor lisinopril, given either alone or in combination in essential hypertension.
Angiotensin converting enzyme (ACE) inhibitors and dihydropyridine calcium antagonists are well established and widely used as monotherapy in patients with mild to moderate essential hypertension. Name must be less than 100 characters
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